Triterpenoids and a sterol from the stem-bark of Styrax japonica and their protein tyrosine phosphatase 1B inhibitory activities

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dc.contributor.authorJ H Kwon-
dc.contributor.authorM J Chang-
dc.contributor.authorH W Seo-
dc.contributor.authorJ H Lee-
dc.contributor.authorB S Min-
dc.contributor.authorM Na-
dc.contributor.authorJ C Kim-
dc.contributor.authorM H Woo-
dc.contributor.authorJ S Choi-
dc.contributor.authorHyeong Kyu Lee-
dc.contributor.authorK Bae-
dc.date.accessioned2017-04-19T09:12:05Z-
dc.date.available2017-04-19T09:12:05Z-
dc.date.issued2008-
dc.identifier.issn0951418X-
dc.identifier.uri10.1002/ptr.2484ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/8681-
dc.description.abstractFive pentacyclic triterpenoids (1-5) and a sterol (6) were isolated from the stem-bark of Styrax japonica. The six compounds, 1-6, were determined to be 3β-acetoxy-28-hydroxyolean-12-ene (1), 3β-acetoxyolean-12-en-28-acid (2), 3β-acetoxyolean-12-en-28-aldehyde (3), 3β-acetoxy-17β- hydroxy-28-norolean-12-ene (4), taraxerol (5) and stigmasterol (6), respectively, by spectroscopic means, including the 2D-NMR technique. Compound 4 is a newly discovered natural compound. The protein tyrosine phosphatase 1B (PTP1B) inhibitory activities of the isolated compounds (1-6) were determined in vitro. Among the isolated compounds, 3β-acetoxyolean-12-en-28-acid (2) and 3β-acetoxyolean-12-en-28-aldehyde (3) had the most potent inhibitory PTP1B activity, with IC50 values of 7.8 and 9.3 μm, respectively.-
dc.publisherWiley-
dc.titleTriterpenoids and a sterol from the stem-bark of Styrax japonica and their protein tyrosine phosphatase 1B inhibitory activities-
dc.title.alternativeTriterpenoids and a sterol from the stem-bark of Styrax japonica and their protein tyrosine phosphatase 1B inhibitory activities-
dc.typeArticle-
dc.citation.titlePhytotherapy Research-
dc.citation.number10-
dc.citation.endPage1306-
dc.citation.startPage1303-
dc.citation.volume22-
dc.contributor.alternativeName권주희-
dc.contributor.alternativeName장민정-
dc.contributor.alternativeName서효원-
dc.contributor.alternativeName이정훈-
dc.contributor.alternativeName민병선-
dc.contributor.alternativeName나민균-
dc.contributor.alternativeName김진철-
dc.contributor.alternativeName우미희-
dc.contributor.alternativeName최재세-
dc.contributor.alternativeName이형규-
dc.contributor.alternativeName배기환-
dc.identifier.bibliographicCitationPhytotherapy Research, vol. 22, no. 10, pp. 1303-1306-
dc.identifier.doi10.1002/ptr.2484-
dc.subject.keyword3β-acetoxyolean- 12-en-28-acid-
dc.subject.keyword3β-acetoxyolean-12-en-28-aldehyde-
dc.subject.keywordPTP1B inhibitory activity-
dc.subject.keywordstyracaceae-
dc.subject.keywordstyrax japonica-
dc.subject.local3β-acetoxyolean- 12-en-28-acid-
dc.subject.local3β-acetoxyolean-12-en-28-aldehyde-
dc.subject.localPTP1B inhibitory activity-
dc.subject.localstyracaceae-
dc.subject.localStyracaceae-
dc.subject.localstyrax japonica-
dc.subject.localStyrax japonica-
dc.description.journalClassY-
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