Antiviral activity of Zanthoxylum species against influenza virus = 인플루엔자 바이러스에 대한 Zanthoxylum속의 항바이러스 효과 검정

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Title
Antiviral activity of Zanthoxylum species against influenza virus = 인플루엔자 바이러스에 대한 Zanthoxylum속의 항바이러스 효과 검정
Author(s)
Hwa-Jung Choi; J H Song; Dur Han Kwon; S H Baek; Y J Ahn
Bibliographic Citation
Korean Journal of Medicinal Crop Science, vol. 16, no. 4, pp. 273-278
Publication Year
2008
Abstract
We aimed to investigate the antiviral activity of Zanthoxylum species against influenza virus A/WS/33, A/PR/8 and B/Lee/40 used by sulforhodamine B (SRB) assay and the action of leaves extracts of Zanthoxylum piperitum on life cycle of influenza virus A/WS/33. Among the twelve extracts, only the leaf extract of Z. piperitum exhibited strong antiviral activity at low concentration of less than 10 ㎍/㎖ with no citotoxicity (50 ㎍/㎖) against all of three viruses. In addition, only oseltamivir showed antiviral activity with IC∧50 of 65.3 ㎍/㎖ against influenza A/WS/33 among the viruses. Furthermore, the leaf extract of Z. piperitum suppressed infection of influenza virus A/WS/33, when added just prior (-1 hr) or after virus inoculation (0 hr). Leaf extract of Z. piperitum directly affect the infectivity of influenza virus A/WS/33 particles. Therefore, Leaf extract of Z. piperitum exhibited higher antiviral activity against three influenza viruses than that of the oseltamivir, which directly interacts with influenza A/WS/33 particles, affecting the initial stages of infection such as receptor binding and virus entry.
Keyword
influenza viruszanthoxylum piperitumoseltamivircytotoxicityantiviral activity
ISSN
I000-0107
Publisher
South Korea
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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