Screening for human ACAT-1 and ACAT-2 inhibitory activity of edible plant extracts = 식물추출물의 Human-ACAT 저해활성 검색

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Title
Screening for human ACAT-1 and ACAT-2 inhibitory activity of edible plant extracts = 식물추출물의 Human-ACAT 저해활성 검색
Author(s)
D Y Lee; Tae Sook Jeong; H N Lyu; M H Bang; Y H Hong; Y H Lee; N I Baek
Bibliographic Citation
Korean Journal of Medicinal Crop Science, vol. 16, no. 5, pp. 341-348
Publication Year
2008
Abstract
Cholesterol acyltransferase (ACAT) catalyzes the acylation of cholesterol to cholesteryl ester with long chain fatty acids and ACAT inhibition is a useful strategy for treating hypercholesterolemia or atherosclerosis. Inhibitory effects on ACAT of the MeOH extracts prepared from 163 edible plants were evaluated. 15 species out of 163 species exhibited higher than 50% of inhibition on the hACAT-1 and 9 species exhibited higher than 50% of inhibition on the hACAT-2 activity at their concentration of .
Keyword
edible plantAcyl-CoAcholesterol acyltransferase (ACAT)hypercholesterolemiaatheroclerosis
ISSN
I000-0107
Publisher
Korea Soc-Assoc-Inst
Type
Article
Appears in Collections:
Division of Biomedical Research > Microbiome Convergence Research Center > 1. Journal Articles
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