Arthroderma vanbreuseghemii isolated from Laboratory New Zealand White rabbits and Hartley guinea pigs with dermatitis

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Title
Arthroderma vanbreuseghemii isolated from Laboratory New Zealand White rabbits and Hartley guinea pigs with dermatitis
Author(s)
Young Suk Won; Hyo Jung Kwon; Y K Choi; Woon Kee YoonSang Woon KimHae Jin Lee; Bon Chul Koo; Sae Bom Lee; Ki Hoan Nam; Og Sung Moon; Hyoung-Chin Kim
Bibliographic Citation
Laboratory Animal Research, vol. 24, no. 3, pp. 439-445
Publication Year
2008
Abstract
Dermatophytes are the most important dermatological zoonosis pathogen. Although it is well known as a transmittable disease from animal to human, control of dermatophyte is still difficult in conventionally housed animals. Laboratory New Zealand White rabbits and Hartley guinea pigs bred in conventional facility were sent to the Korea Research Institute of Biotechnology and Biology for health monitoring. Two of five rabbits and six of ten guinea-pigs had discrete, irregularly shaped and encrusted alopecia around eye, legs, mouth and thigh area. Histopathologically, epidermis showed hyperkeratosis, parakeratosis and acantosis. Dermis and hair follicle were infiltrated with numerous neutrophils, macrophages and lymphocytes. The PAS staining demonstrated large numbers of arthrospores and branched hyphae within stratum corneum and hair follicle. Fungal culture of the skin lesions revealed characteristic fungi colony and conidia of Trichophyton mentagrophyte. For rapid identification of this fungus using molecular method, we performed ITS gene specific PCR and sequenced the products. Results of ITS gene sequencing, our isolates have very similar sequence with previous reported Arthroderma vanbreuseghemii. These results suggest that our isolated fungi could be cause of these rabbits and guinea pigs dermal disease.
Keyword
dermatophytetrichophyton mentagrophytehartley guinea pigNew Zealand White rabbit
ISSN
1738-6055
Publisher
Springer-BMC
Type
Article
Appears in Collections:
Ochang Branch Institute > Division of National Bio-Infrastructure > Laboratory Animal Resource & Research Center > 1. Journal Articles
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