Bavachin and isobavachalcone, acyl-coenzyme A: cholesterol acyltransferase inhibitors from Psoralea corylifolia = 파고지로부터 분리한 ACAT저해물질 bavachin과 isobavachalcone

Cited 30 time in scopus
Metadata Downloads

Full metadata record

DC FieldValueLanguage
dc.contributor.authorJung Ho Choi-
dc.contributor.authorMun Chual Rho-
dc.contributor.authorSeung Woong Lee-
dc.contributor.authorJi Na Choi-
dc.contributor.authorK Kim-
dc.contributor.authorG Y Song-
dc.contributor.authorYoung Kook Kim-
dc.date.accessioned2017-04-19T09:12:13Z-
dc.date.available2017-04-19T09:12:13Z-
dc.date.issued2008-
dc.identifier.issn0253-6269-
dc.identifier.uri10.1007/s12272-001-2126-xko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/8712-
dc.description.abstractAcyl-coenzyme A: cholesterol acyltransferase (ACAT) catalyzes cholesterol esterification and plays important roles in intestinal absorption of cholesterol, hepatic production of lipoproteins and accumulation of cholesteryl ester within macrophages and smooth muscle cells. Ethanol extract of Psoralea corylifolia showed a significant inhibition of ACAT enzyme. Via bioactivity-guided fractionation of the ethanol extract of Psoralea corylifolia, two prenylated flavonoids were isolated. Their structures were determined as bavachin (1) and isobavachalcone (2) by spectroscopic analysis (1H-, 13C-NMR, 2DNMR, and ESI-MS). The IC50 values were 86.0 (1) and 48.0 (2) μM in the ACAT assay system using rat liver microsome. Compound 2 also decreased cholesteryl ester formations in HepG2 cells. In addition, this compound showed a noncompetitive type of inhibition of ACAT.-
dc.publisherPharmaceutical Soc Korea-
dc.titleBavachin and isobavachalcone, acyl-coenzyme A: cholesterol acyltransferase inhibitors from Psoralea corylifolia = 파고지로부터 분리한 ACAT저해물질 bavachin과 isobavachalcone-
dc.title.alternativeBavachin and isobavachalcone, acyl-coenzyme A: cholesterol acyltransferase inhibitors from Psoralea corylifolia-
dc.typeArticle-
dc.citation.titleArchives of Pharmacal Research-
dc.citation.number11-
dc.citation.endPage1423-
dc.citation.startPage1419-
dc.citation.volume31-
dc.contributor.affiliatedAuthorJung Ho Choi-
dc.contributor.affiliatedAuthorMun Chual Rho-
dc.contributor.affiliatedAuthorSeung Woong Lee-
dc.contributor.affiliatedAuthorJi Na Choi-
dc.contributor.affiliatedAuthorYoung Kook Kim-
dc.contributor.alternativeName최정호-
dc.contributor.alternativeName노문철-
dc.contributor.alternativeName이승웅-
dc.contributor.alternativeName최지나-
dc.contributor.alternativeName김관회-
dc.contributor.alternativeName송규용-
dc.contributor.alternativeName김영국-
dc.identifier.bibliographicCitationArchives of Pharmacal Research, vol. 31, no. 11, pp. 1419-1423-
dc.identifier.doi10.1007/s12272-001-2126-x-
dc.subject.keywordAcyl-coenzyme A: cholesterol acyltransferase (ACAT)-
dc.subject.keywordAtherosclerosis-
dc.subject.keywordEnzyme assay-
dc.subject.keywordHypolipidemia-
dc.subject.keywordPrenylated flavonoids-
dc.subject.keywordPsoralea corylifolia-
dc.subject.localACAT (acyl-CoA: cholesterol acyltransferase)-
dc.subject.localAcyl-CoA:cholesterol acyltransferase (ACAT)-
dc.subject.localcholesterol acytransferase (ACAT)-
dc.subject.localCholestrol Acyl Transferase (ACAT)-
dc.subject.localAcyl CoA: cholesterol acyltransferase (ACAT)-
dc.subject.localACAT (Acyl-CoA:cholesterol acyltransferase)-
dc.subject.localAcyl-CoA:cholesterol acyltransferase-
dc.subject.localACAT-
dc.subject.localAcyl-CoA: cholesterol acyltransferase-
dc.subject.localacyl-CoA:cholesterol acyltransferase (ACAT)-
dc.subject.localAcyl-CoA: cholesterol acyltransferase (ACAT)-
dc.subject.localAcyl-coenzyme A: cholesterol acyltransferase (ACAT)-
dc.subject.localCholesterol acytransferase (ACAT)-
dc.subject.localcholestrol acyl transferase (ACAT)-
dc.subject.localatherosclerosis-
dc.subject.localAtherosclerosis-
dc.subject.localatheroclerosis-
dc.subject.localEnzyme Assay-
dc.subject.localEnzyme assay-
dc.subject.localHypolipidemia-
dc.subject.localPrenylated flavonoids-
dc.subject.localPsoralea corylifolia L.-
dc.subject.localPsoralea corylifolia-
dc.description.journalClassY-
Appears in Collections:
Jeonbuk Branch Institute > Functional Biomaterial Research Center > 1. Journal Articles
Files in This Item:
  • There are no files associated with this item.


Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.