DC Field | Value | Language |
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dc.contributor.author | Jung Ho Choi | - |
dc.contributor.author | Mun Chual Rho | - |
dc.contributor.author | Seung Woong Lee | - |
dc.contributor.author | Ji Na Choi | - |
dc.contributor.author | K Kim | - |
dc.contributor.author | G Y Song | - |
dc.contributor.author | Young Kook Kim | - |
dc.date.accessioned | 2017-04-19T09:12:13Z | - |
dc.date.available | 2017-04-19T09:12:13Z | - |
dc.date.issued | 2008 | - |
dc.identifier.issn | 0253-6269 | - |
dc.identifier.uri | 10.1007/s12272-001-2126-x | ko |
dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/8712 | - |
dc.description.abstract | Acyl-coenzyme A: cholesterol acyltransferase (ACAT) catalyzes cholesterol esterification and plays important roles in intestinal absorption of cholesterol, hepatic production of lipoproteins and accumulation of cholesteryl ester within macrophages and smooth muscle cells. Ethanol extract of Psoralea corylifolia showed a significant inhibition of ACAT enzyme. Via bioactivity-guided fractionation of the ethanol extract of Psoralea corylifolia, two prenylated flavonoids were isolated. Their structures were determined as bavachin (1) and isobavachalcone (2) by spectroscopic analysis (1H-, 13C-NMR, 2DNMR, and ESI-MS). The IC50 values were 86.0 (1) and 48.0 (2) μM in the ACAT assay system using rat liver microsome. Compound 2 also decreased cholesteryl ester formations in HepG2 cells. In addition, this compound showed a noncompetitive type of inhibition of ACAT. | - |
dc.publisher | Pharmaceutical Soc Korea | - |
dc.title | Bavachin and isobavachalcone, acyl-coenzyme A: cholesterol acyltransferase inhibitors from Psoralea corylifolia = 파고지로부터 분리한 ACAT저해물질 bavachin과 isobavachalcone | - |
dc.title.alternative | Bavachin and isobavachalcone, acyl-coenzyme A: cholesterol acyltransferase inhibitors from Psoralea corylifolia | - |
dc.type | Article | - |
dc.citation.title | Archives of Pharmacal Research | - |
dc.citation.number | 11 | - |
dc.citation.endPage | 1423 | - |
dc.citation.startPage | 1419 | - |
dc.citation.volume | 31 | - |
dc.contributor.affiliatedAuthor | Jung Ho Choi | - |
dc.contributor.affiliatedAuthor | Mun Chual Rho | - |
dc.contributor.affiliatedAuthor | Seung Woong Lee | - |
dc.contributor.affiliatedAuthor | Ji Na Choi | - |
dc.contributor.affiliatedAuthor | Young Kook Kim | - |
dc.contributor.alternativeName | 최정호 | - |
dc.contributor.alternativeName | 노문철 | - |
dc.contributor.alternativeName | 이승웅 | - |
dc.contributor.alternativeName | 최지나 | - |
dc.contributor.alternativeName | 김관회 | - |
dc.contributor.alternativeName | 송규용 | - |
dc.contributor.alternativeName | 김영국 | - |
dc.identifier.bibliographicCitation | Archives of Pharmacal Research, vol. 31, no. 11, pp. 1419-1423 | - |
dc.identifier.doi | 10.1007/s12272-001-2126-x | - |
dc.subject.keyword | Acyl-coenzyme A: cholesterol acyltransferase (ACAT) | - |
dc.subject.keyword | Atherosclerosis | - |
dc.subject.keyword | Enzyme assay | - |
dc.subject.keyword | Hypolipidemia | - |
dc.subject.keyword | Prenylated flavonoids | - |
dc.subject.keyword | Psoralea corylifolia | - |
dc.subject.local | ACAT (acyl-CoA: cholesterol acyltransferase) | - |
dc.subject.local | Acyl-CoA:cholesterol acyltransferase (ACAT) | - |
dc.subject.local | cholesterol acytransferase (ACAT) | - |
dc.subject.local | Cholestrol Acyl Transferase (ACAT) | - |
dc.subject.local | Acyl CoA: cholesterol acyltransferase (ACAT) | - |
dc.subject.local | ACAT (Acyl-CoA:cholesterol acyltransferase) | - |
dc.subject.local | Acyl-CoA:cholesterol acyltransferase | - |
dc.subject.local | ACAT | - |
dc.subject.local | Acyl-CoA: cholesterol acyltransferase | - |
dc.subject.local | acyl-CoA:cholesterol acyltransferase (ACAT) | - |
dc.subject.local | Acyl-CoA: cholesterol acyltransferase (ACAT) | - |
dc.subject.local | Acyl-coenzyme A: cholesterol acyltransferase (ACAT) | - |
dc.subject.local | Cholesterol acytransferase (ACAT) | - |
dc.subject.local | cholestrol acyl transferase (ACAT) | - |
dc.subject.local | atherosclerosis | - |
dc.subject.local | Atherosclerosis | - |
dc.subject.local | atheroclerosis | - |
dc.subject.local | Enzyme Assay | - |
dc.subject.local | Enzyme assay | - |
dc.subject.local | Hypolipidemia | - |
dc.subject.local | Prenylated flavonoids | - |
dc.subject.local | Psoralea corylifolia L. | - |
dc.subject.local | Psoralea corylifolia | - |
dc.description.journalClass | Y | - |
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