Evaluation of oxy-radical scavenging capacity of fucoidan = Fucoidan의 oxy-radical 포획능 평가

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Title
Evaluation of oxy-radical scavenging capacity of fucoidan = Fucoidan의 oxy-radical 포획능 평가
Author(s)
B H Kim; J M Oh; K W Kang; S H Kwak; S Y Yun; Chul Ho Lee; Hyun Sun Lee; S K Kim
Bibliographic Citation
Journal of Environmental Toxicology, vol. 23, no. 1, pp. 41-45
Publication Year
2008
Abstract
Algal fucoidan is a marine polysaccharide containing sulfur with a wide variety of biological activities including anti-inflammatory and anti-thrombotic effects. Although antioxidants can inhibit inflammatory signals through inhibiting activator protein-1 and/or nuclear factor-kappaB activation, it is obscure whether fucoidan directly scavenges oxy-radicals or indirectly regulates oxidant production and/or antioxidant defense system The antioxidant activities of fucoidan against peroxyl radicals, peroxynitrites and hydroxyl radicals were determined by the total oxy-radical scavenging capacity (TOSC) assay. The specific TOSC values of fucoidan against peroxyl radicals, peroxynitrites or hydroxyl radicals were 282±60, 43±1 or 40±1 TOSC/mg/mL, respectively. These specific TOSC values against peroxyl radicals, peroxynitrites or hydroxyl radicals are 23, 12, or 13% of the specific TOSC values of glutathione, a positive control, respectively. These results suggest that fucoidan has direct oxy-radical scavenging capacity, which may be related with anti-inflammatory effect of fucoidan.
Keyword
fucoidanoxy-radicalsTOSCoxidative stress
ISSN
1226-9158
Publisher
Korea Soc-Assoc-Inst
Type
Article
Appears in Collections:
Ochang Branch Institute > Division of National Bio-Infrastructure > Laboratory Animal Resource & Research Center > 1. Journal Articles
Ochang Branch Institute > Natural Product Research Center > 1. Journal Articles
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