Regioselective synthesis of poly-substituted pyrroles from baylis-hillman adducts via the [3+1+N] annulation strategy = 다중치환된 피롤 화합물합성

Abstract

Poly-substituted pyrrole derivatives were synthesized from Baylis-Hillman adducts via the following consecutive reactions comprised of (i) bromination of the Baylis-Hillman adduct, (ii) In-mediated Barbier reaction with aldehyde, (iii) PCC oxidation to α-methylene-γ-keto ester, (iv) reaction with amine to form enamine intermediate, (v) Michael type cyclization, and the final (vi) aerobic oxidation.