Regioselective synthesis of poly-substituted pyrroles from baylis-hillman adducts via the [3+1+N] annulation strategy = 다중치환된 피롤 화합물합성

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Title
Regioselective synthesis of poly-substituted pyrroles from baylis-hillman adducts via the [3+1+N] annulation strategy = 다중치환된 피롤 화합물합성
Author(s)
J M Kim; Sangku Lee; S H Kim; H S Lee; J N Kim
Bibliographic Citation
Bulletin of Korean Chemical Society, vol. 29, no. 11, pp. 2215-2220
Publication Year
2008
Abstract
Poly-substituted pyrrole derivatives were synthesized from Baylis-Hillman adducts via the following consecutive reactions comprised of (i) bromination of the Baylis-Hillman adduct, (ii) In-mediated Barbier reaction with aldehyde, (iii) PCC oxidation to α-methylene-γ-keto ester, (iv) reaction with amine to form enamine intermediate, (v) Michael type cyclization, and the final (vi) aerobic oxidation.
Keyword
aerobic oxidationbarbier reactionbaylis-hillman adductsPCCpyrroles
ISSN
0253-2964
Publisher
Wiley
DOI
http://dx.doi.org/10.5012/bkcs.2008.29.11.2215
Type
Article
Appears in Collections:
Ochang Branch Institute > Chemical Biology Research Center > 1. Journal Articles
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