Phytochemical investigation of Tiarella polyphylla

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Title
Phytochemical investigation of Tiarella polyphylla
Author(s)
G Shen; Sei Ryang Oh; B S Min; Joongku Lee; Kyung Seop Ahn; Y H Kim; Hyeong Kyu Lee
Bibliographic Citation
Archives of Pharmacal Research, vol. 31, no. 1, pp. 10-16
Publication Year
2008
Abstract
Seven flavonoids (1-7), two triterpenoids (8 and 9) and four steroids (10, 11, 12 and 13) were isolated from the whole plant of Tiarella polyphylla. Based on the physicochemical and spectroscopic analyses, their structures were identified as myricetin (1), astragalin (2), afzelin (3), quercitrin (4), myricitin (5), nicotiflorin (6), isoquercitrin (7), tiarellic acid (8), 3β-hydroxy-20(29)lupen-27-oic acid (9), β-sitosterol-3-O-β-D- glucoside (10), stigmasterol-3-O-β-D-glucoside (11), β-sitosterol (12) and ergosterol endoperoxide (13). All 13 compounds, with the exception of tiarellic acid were isolated for the first time from T. polyphylla. In the anti-complementary assay, the steroids (12 and 13) exhibited potent activities; whereas, the flavonoids (1 to 7) showed weak or no activities, but even the triterpenoids (8 and 9) and steroidal saponins (10 and 11) evoked hemolysis. ⓒ 2008 The Pharmaceutical Society of Korea.
Keyword
anti-complementary activityflavonoidssaxifragaceaesteroidstiarella polyphyllatriterpenoids
ISSN
0253-6269
Publisher
Pharmaceutical Soc Korea
DOI
http://dx.doi.org/10.1007/s12272-008-1113-x
Type
Article
Appears in Collections:
Ochang Branch Institute > 1. Journal Articles
Ochang Branch Institute > Natural Product Research Center > 1. Journal Articles
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