Alcohol enhances Abeta42-induced neuronal cell death through mitochondrial dysfunction

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Title
Alcohol enhances Abeta42-induced neuronal cell death through mitochondrial dysfunction
Author(s)
D Y Lee; Kyu-Sun Lee; H J Lee; H Y Jung; J Y Lee; S H Lee; Y C Youn; K M Seo; J H Lee; W B Lee; S S Kim
Bibliographic Citation
FEBS Letters, vol. 582, no. 30, pp. 4185-4190
Publication Year
2008
Abstract
Mitochondrial dysfunction is a hallmark of beta-amyloid (Abeta)-induced neuronal toxicity in Alzheimer's disease (AD). Epidemiological studies have indicated that alcohol consumption plays a role in the development of AD. Here we show that alcohol exposure has a synergistic effect on Abeta-induced neuronal cell death. Abeta-treated cultured neurons displayed spontaneous generation of reactive oxygen species (ROS), disruption of their mitochondrial membrane potential, induction of caspase-3 and p53 activities, and loss of cell viability. Alcohol exposure facilitated Abeta-induced neuronal cell death. Our study shows that alcohol consumption enhances Abeta-induced neuronal cell death by increasing ROS and mitochondrial dysfunction.
Keyword
Alzheimer's diseaseEthanolMitochondriaROS
ISSN
0014-5793
Publisher
Wiley
DOI
http://dx.doi.org/10.1016/j.febslet.2008.11.007
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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