Glycoproteomic analysis of plasma from patients with atopic dermatitis: CD5L and ApoE as potential biomarkers = 아토피 환자의 혈청 단백질체 분석

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dc.contributor.authorWon Kon-Kim-
dc.contributor.authorH R Hwang-
dc.contributor.authorDo-Hyoung Kim-
dc.contributor.authorPhil Young Lee-
dc.contributor.authorY J In-
dc.contributor.authorH Y Ryu-
dc.contributor.authorSung Goo Park-
dc.contributor.authorKwang-Hee Bae-
dc.contributor.authorSang Chul Lee-
dc.date.accessioned2017-04-19T09:12:36Z-
dc.date.available2017-04-19T09:12:36Z-
dc.date.issued2008-
dc.identifier.issnI000-0028-
dc.identifier.uri10.3858/emm.2008.40.6.677ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/8755-
dc.description.abstractAtopic dermatitis (AD) is an inflammatory skin disorder that is both uncomfortable and distressing to patients, and its prevalence has been steadily increasing. It is obvious that the identification of efficient markers of AD in plasma would offer the possibility of effective diagnosis, prevention, and treatment strategies. In this study, a proteomic approach was used to analyze plasma glycoproteins from both children with AD and healthy child donors. Several protein spots showing significant quantitative changes in the AD patients were identified. Through sequential studies, it was confirmed that CD5L and ApoE were significantly up-regulated or down-regulated, respectively, in the plasma from AD patients compared with that from healthy donors. In addition, we suggest that the up-regulated CD5L in AD patients causes eosinophilia by inhibiting apoptosis or promoting the proliferation of eosinophils either in combination with or without IL-5. The glycoproteomic data in this study provides clues to understanding the mechanism of atopic alterations in plasma and suggests AD-related proteins can be used as candidate markers for AD.-
dc.publisherSpringer-Nature Pub Group-
dc.titleGlycoproteomic analysis of plasma from patients with atopic dermatitis: CD5L and ApoE as potential biomarkers = 아토피 환자의 혈청 단백질체 분석-
dc.title.alternativeGlycoproteomic analysis of plasma from patients with atopic dermatitis: CD5L and ApoE as potential biomarkers-
dc.typeArticle-
dc.citation.titleExperimental and Molecular Medicine-
dc.citation.number6-
dc.citation.endPage685-
dc.citation.startPage677-
dc.citation.volume40-
dc.contributor.affiliatedAuthorWon Kon-Kim-
dc.contributor.affiliatedAuthorDo-Hyoung Kim-
dc.contributor.affiliatedAuthorPhil Young Lee-
dc.contributor.affiliatedAuthorSung Goo Park-
dc.contributor.affiliatedAuthorKwang-Hee Bae-
dc.contributor.affiliatedAuthorSang Chul Lee-
dc.contributor.alternativeName김원곤-
dc.contributor.alternativeName황향란-
dc.contributor.alternativeName김도형-
dc.contributor.alternativeName이필영-
dc.contributor.alternativeName인유정-
dc.contributor.alternativeName유혜영-
dc.contributor.alternativeName박성구-
dc.contributor.alternativeName배광희-
dc.contributor.alternativeName이상철-
dc.identifier.bibliographicCitationExperimental and Molecular Medicine, vol. 40, no. 6, pp. 677-685-
dc.identifier.doi10.3858/emm.2008.40.6.677-
dc.subject.keywordApolipoproteins E-
dc.subject.keywordCD5L protein, human-
dc.subject.keywordDermatitis, atopic-
dc.subject.keywordGlycoproteins-
dc.subject.keywordPlasma-
dc.subject.keywordProteomics-
dc.subject.localApolipoproteins E-
dc.subject.localCD5L protein, human-
dc.subject.localDermatitis, atopic-
dc.subject.localGlycoprotein-
dc.subject.localGlycoproteins-
dc.subject.localglycoprotein-
dc.subject.localglycoproteins-
dc.subject.localPlasma-
dc.subject.localplasma-
dc.subject.localProteomic-
dc.subject.localProteomics-
dc.description.journalClassY-
Appears in Collections:
Division of Biomedical Research > Metabolic Regulation Research Center > 1. Journal Articles
Division of Bio Technology Innovation > Core Research Facility & Analysis Center > 1. Journal Articles
Division of Biomedical Research > Disease Target Structure Research Center > 1. Journal Articles
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