Hepatitis B virus-X protein recruits histone deacetylase 1 to repress insulin-like growth factor binding protein 3 transcription

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Title
Hepatitis B virus-X protein recruits histone deacetylase 1 to repress insulin-like growth factor binding protein 3 transcription
Author(s)
J K Shon; Bo Hwa Shon; In-Young Park; Su Ui Lee; L Fa; K Y Chang; J H SHin; Young Ik Lee
Bibliographic Citation
Virus Research, vol. 139, no. 1, pp. 14-21
Publication Year
2009
Abstract
Hepatitis B virus (HBV), a major causative agent of hepatocelluar carcinoma (HCC), encodes an oncogenic X-protein (HBx) which has been known as a transcriptional transactivator on multiple viral and celluar promoters. In the report, we verified that HBx transcriptionally repress insulin-like growth factor binding protein-3 (IGFBP-3) by promoting HBx/histone deacetylase 1 (HDAC1) complex formation. HBx recruited HDAC1 forms complex with Sp1 in a p53-independent manner) and deacetylates Sp1 which resulted in the diminished binding of Sp1 on targeted DNA during transcriptional repression. Deacetylation of Sp1 by HBx recruited HDAC1 likely to be a part of the mechanism that controls HBx induced IGFBP-3 repression and the modification of chromatin structure.
Keyword
chromatin immunoprecipitationhistone deacetylase 1immunoprecipitationinsulin-like growth factor binding protein-3insulin-like growth factor type 1trichostatin A
ISSN
0168-1702
Publisher
Elsevier
DOI
http://dx.doi.org/10.1016/j.virusres.2008.09.006
Type
Article
Appears in Collections:
Ochang Branch Institute > Natural Medicine Research Center > 1. Journal Articles
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