Construction and performance test of a multiplexed multistage (MSn) time-of-flight mass spectrometer

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Title
Construction and performance test of a multiplexed multistage (MSn) time-of-flight mass spectrometer
Author(s)
Y S Shin; Jeong Hee Moon; M S Kim
Bibliographic Citation
Analytical Chemistry, vol. 80, no. 24, pp. 9700-9704
Publication Year
2008
Abstract
A time-of-flight mass spectrometer equipped with two reflectrons was constructed for multiplexed photodissociation tandem mass spectrometry of peptide ions generated by matrix-assisted laser desorption ionization. A linear reflectron was used for high-resolution selection of a precursor ion while a quadratic reflectron was used for product ion analysis. With the photoexcitation of a precursor ion inside a cell floated at high voltage, information (MS 3) on intermediate ions generating a particular product ion was obtained. Fully multiplexed detection resulted in good MS3 signal levels. Use of the quadratic reflectron allowed intermediate ion mass determination within 4 Da. The possibility of further extending the technique and its analytical potential are discussed.
ISSN
0003-2700
Publisher
Amer Chem Soc
DOI
http://dx.doi.org/10.1021/ac801675r
Type
Article
Appears in Collections:
Division of Biomedical Research > Disease Target Structure Research Center > 1. Journal Articles
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