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- Title
- Construction and performance test of a multiplexed multistage (MSn) time-of-flight mass spectrometer
- Author(s)
- Y S Shin; Jeong Hee Moon; M S Kim
- Bibliographic Citation
- Analytical Chemistry, vol. 80, no. 24, pp. 9700-9704
- Publication Year
- 2008
- Abstract
- A time-of-flight mass spectrometer equipped with two reflectrons was constructed for multiplexed photodissociation tandem mass spectrometry of peptide ions generated by matrix-assisted laser desorption ionization. A linear reflectron was used for high-resolution selection of a precursor ion while a quadratic reflectron was used for product ion analysis. With the photoexcitation of a precursor ion inside a cell floated at high voltage, information (MS 3) on intermediate ions generating a particular product ion was obtained. Fully multiplexed detection resulted in good MS3 signal levels. Use of the quadratic reflectron allowed intermediate ion mass determination within 4 Da. The possibility of further extending the technique and its analytical potential are discussed.
- ISSN
- 0003-2700
- Publisher
- Amer Chem Soc
- DOI
- http://dx.doi.org/10.1021/ac801675r
- Type
- Article
- Appears in Collections:
- Division of Bio Technology Innovation > Core Research Facility & Analysis Center > 1. Journal Articles
- Files in This Item:
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