Transcriptome analysis of the zebrafish mind bomb mutant

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dc.contributor.authorJ Hwang-
dc.contributor.authorH S Kim-
dc.contributor.authorJ W Seok-
dc.contributor.authorJ D Kim-
dc.contributor.authorS Koun-
dc.contributor.authorS Y Park-
dc.contributor.authorJ Lee-
dc.contributor.authorH S Kim-
dc.contributor.authorH S Kim-
dc.contributor.authorK S Kim-
dc.contributor.authorKyu Tae Chang-
dc.contributor.authorZ Y Ryoo-
dc.contributor.authorS M Wang-
dc.contributor.authorT L Huh-
dc.contributor.authorS Lee-
dc.date.accessioned2017-04-19T09:12:53Z-
dc.date.available2017-04-19T09:12:53Z-
dc.date.issued2009-
dc.identifier.issn0026-8925-
dc.identifier.uri10.1007/s00438-008-0395-5ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/8798-
dc.description.abstractMind bomb (Mib) facilitates Notch signaling pathway by promoting the endocytosis of Notch ligand. The zebrafish mibta52b mutant has a defect in its ubiquitin ligase activity which is necessary to inhibit the neurogenesis, resulting in a neuronal hyperplasia. Several genes regulated in the mibta52b mutant have been well established, however, there were relatively few reports about the transcriptome profile. To identify the genes differentially expressed in the mibta52b mutant, genome-wide analysis was performed using serial analysis of gene expression. Three hundred and thirty-five transcripts were identified whose expressions were significantly altered in the mibta52b mutant as compared with the wild-type. Interestingly, it was suggested that the mibta52b mutation may affect not only neurogenesis but also mesoderm development. These results provide new insights into Notch signaling pathway.-
dc.publisherSpringer-
dc.titleTranscriptome analysis of the zebrafish mind bomb mutant-
dc.title.alternativeTranscriptome analysis of the zebrafish mind bomb mutant-
dc.typeArticle-
dc.citation.titleMolecular Genetics and Genomics-
dc.citation.number1-
dc.citation.endPage85-
dc.citation.startPage77-
dc.citation.volume281-
dc.contributor.affiliatedAuthorKyu Tae Chang-
dc.contributor.alternativeName황준모-
dc.contributor.alternativeName김형수-
dc.contributor.alternativeName석지웅-
dc.contributor.alternativeName김준대-
dc.contributor.alternativeName권순일-
dc.contributor.alternativeName박소영-
dc.contributor.alternativeName이진석-
dc.contributor.alternativeName김향숙-
dc.contributor.alternativeName김형석-
dc.contributor.alternativeName김길수-
dc.contributor.alternativeName장규태-
dc.contributor.alternativeName류재웅-
dc.contributor.alternativeNameWang-
dc.contributor.alternativeName허태린-
dc.contributor.alternativeName이상규-
dc.identifier.bibliographicCitationMolecular Genetics and Genomics, vol. 281, no. 1, pp. 77-85-
dc.identifier.doi10.1007/s00438-008-0395-5-
dc.subject.keywordgenome-wide analysis-
dc.subject.keywordmind bomb-
dc.subject.keywordSAGE-
dc.subject.keywordtranscriptome-
dc.subject.localgenome-wide analysis-
dc.subject.localmind bomb-
dc.subject.localSAGE-
dc.subject.localTranscriptomes-
dc.subject.localtranscriptome-
dc.subject.localTranscriptome-
dc.description.journalClassY-
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