DC Field | Value | Language |
---|---|---|
dc.contributor.author | Y J Kim | - |
dc.contributor.author | Jae Won Huh | - |
dc.contributor.author | Dae Soo Kim | - |
dc.contributor.author | M I Bae | - |
dc.contributor.author | J R Lee | - |
dc.contributor.author | H S Ha | - |
dc.contributor.author | K Ahn | - |
dc.contributor.author | T O Kim | - |
dc.contributor.author | G A Song | - |
dc.contributor.author | H S Kim | - |
dc.date.accessioned | 2017-04-19T09:13:06Z | - |
dc.date.available | 2017-04-19T09:13:06Z | - |
dc.date.issued | 2009 | - |
dc.identifier.issn | 0171-5216 | - |
dc.identifier.uri | 10.1007/s00432-008-0445-8 | ko |
dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/8801 | - |
dc.description.abstract | Purpose: DYX1C1 has three alternatively spliced transcripts. Therefore, we expect that alternative transcripts of DYX1C1 are used as a biomarker to detect specific cancer. Methods: RT-PCR analysis is conducted in order to detect expression of the DYX1C1 gene and the PCR products were analyzed using the Image J program to compare the expression levels of each transcript. Results: We found one of the transcripts was directly associated with an HERV-H LTR element that could be translated into protein sequence. Four new alternative transcripts were identified by RT-PCR analysis with various human tissue samples including 10 normal and adjacent tumor tissue sets. Semi-quantitative RT-PCR analysis showed the transcriptional activity of V3 and V2 was higher in tumor than in normal tissue samples, especially in the colorectal tissue samples. Conclusion: Our results indicated that alternatively spliced transcript variants of the DYX1C1 gene could be used as cancer biomarkers to detect colorectal cancer. | - |
dc.publisher | Springer | - |
dc.title | Molecular characterization of the DYX1C1 gene and its application as a cancer biomarker | - |
dc.title.alternative | Molecular characterization of the DYX1C1 gene and its application as a cancer biomarker | - |
dc.type | Article | - |
dc.citation.title | Journal of Cancer Research and Clinical Oncology | - |
dc.citation.number | 2 | - |
dc.citation.endPage | 270 | - |
dc.citation.startPage | 265 | - |
dc.citation.volume | 135 | - |
dc.contributor.affiliatedAuthor | Jae Won Huh | - |
dc.contributor.affiliatedAuthor | Dae Soo Kim | - |
dc.contributor.alternativeName | 김윤지 | - |
dc.contributor.alternativeName | 허재원 | - |
dc.contributor.alternativeName | 김대수 | - |
dc.contributor.alternativeName | 배민인 | - |
dc.contributor.alternativeName | 이자랑 | - |
dc.contributor.alternativeName | 하홍석 | - |
dc.contributor.alternativeName | 안경 | - |
dc.contributor.alternativeName | 김태오 | - |
dc.contributor.alternativeName | 송근암 | - |
dc.contributor.alternativeName | 김희수 | - |
dc.identifier.bibliographicCitation | Journal of Cancer Research and Clinical Oncology, vol. 135, no. 2, pp. 265-270 | - |
dc.identifier.doi | 10.1007/s00432-008-0445-8 | - |
dc.subject.keyword | alternative splicing | - |
dc.subject.keyword | dyslexia susceptibility 1 candidate 1 (DYX1C1) | - |
dc.subject.keyword | human endogenous retrovirus (HERV) | - |
dc.subject.keyword | long terminal repeat (LTR) | - |
dc.subject.local | Alternative splicing | - |
dc.subject.local | alternative splicing | - |
dc.subject.local | dyslexia susceptibility 1 candidate 1 (DYX1C1) | - |
dc.subject.local | human endogenous retrovirus (HERV) | - |
dc.subject.local | Long terminal repeats (LTRs) | - |
dc.subject.local | long terminal repeat | - |
dc.subject.local | long terminal repeat (LTR) | - |
dc.subject.local | long terminal repeats | - |
dc.subject.local | Long terminal repeat | - |
dc.description.journalClass | Y | - |
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