Molecular characterization of the DYX1C1 gene and its application as a cancer biomarker

Cited 14 time in scopus
Metadata Downloads

Full metadata record

DC FieldValueLanguage
dc.contributor.authorY J Kim-
dc.contributor.authorJae Won Huh-
dc.contributor.authorDae Soo Kim-
dc.contributor.authorM I Bae-
dc.contributor.authorJ R Lee-
dc.contributor.authorH S Ha-
dc.contributor.authorK Ahn-
dc.contributor.authorT O Kim-
dc.contributor.authorG A Song-
dc.contributor.authorH S Kim-
dc.date.accessioned2017-04-19T09:13:06Z-
dc.date.available2017-04-19T09:13:06Z-
dc.date.issued2009-
dc.identifier.issn0171-5216-
dc.identifier.uri10.1007/s00432-008-0445-8ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/8801-
dc.description.abstractPurpose: DYX1C1 has three alternatively spliced transcripts. Therefore, we expect that alternative transcripts of DYX1C1 are used as a biomarker to detect specific cancer. Methods: RT-PCR analysis is conducted in order to detect expression of the DYX1C1 gene and the PCR products were analyzed using the Image J program to compare the expression levels of each transcript. Results: We found one of the transcripts was directly associated with an HERV-H LTR element that could be translated into protein sequence. Four new alternative transcripts were identified by RT-PCR analysis with various human tissue samples including 10 normal and adjacent tumor tissue sets. Semi-quantitative RT-PCR analysis showed the transcriptional activity of V3 and V2 was higher in tumor than in normal tissue samples, especially in the colorectal tissue samples. Conclusion: Our results indicated that alternatively spliced transcript variants of the DYX1C1 gene could be used as cancer biomarkers to detect colorectal cancer.-
dc.publisherSpringer-
dc.titleMolecular characterization of the DYX1C1 gene and its application as a cancer biomarker-
dc.title.alternativeMolecular characterization of the DYX1C1 gene and its application as a cancer biomarker-
dc.typeArticle-
dc.citation.titleJournal of Cancer Research and Clinical Oncology-
dc.citation.number2-
dc.citation.endPage270-
dc.citation.startPage265-
dc.citation.volume135-
dc.contributor.affiliatedAuthorJae Won Huh-
dc.contributor.affiliatedAuthorDae Soo Kim-
dc.contributor.alternativeName김윤지-
dc.contributor.alternativeName허재원-
dc.contributor.alternativeName김대수-
dc.contributor.alternativeName배민인-
dc.contributor.alternativeName이자랑-
dc.contributor.alternativeName하홍석-
dc.contributor.alternativeName안경-
dc.contributor.alternativeName김태오-
dc.contributor.alternativeName송근암-
dc.contributor.alternativeName김희수-
dc.identifier.bibliographicCitationJournal of Cancer Research and Clinical Oncology, vol. 135, no. 2, pp. 265-270-
dc.identifier.doi10.1007/s00432-008-0445-8-
dc.subject.keywordalternative splicing-
dc.subject.keyworddyslexia susceptibility 1 candidate 1 (DYX1C1)-
dc.subject.keywordhuman endogenous retrovirus (HERV)-
dc.subject.keywordlong terminal repeat (LTR)-
dc.subject.localAlternative splicing-
dc.subject.localalternative splicing-
dc.subject.localdyslexia susceptibility 1 candidate 1 (DYX1C1)-
dc.subject.localhuman endogenous retrovirus (HERV)-
dc.subject.localLong terminal repeats (LTRs)-
dc.subject.locallong terminal repeat-
dc.subject.locallong terminal repeat (LTR)-
dc.subject.locallong terminal repeats-
dc.subject.localLong terminal repeat-
dc.description.journalClassY-
Appears in Collections:
Ochang Branch Institute > Division of National Bio-Infrastructure > National Primate Research Center > 1. Journal Articles
Files in This Item:
  • There are no files associated with this item.


Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.