Identification and characterization of human genes targeted by natural selection = 자연선택에 의한 인간유전자의 변이 특성화 연구

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dc.contributor.authorH J Ryu-
dc.contributor.authorYoung Joo Kim-
dc.contributor.authorY K Park-
dc.contributor.authorJ J Kim-
dc.contributor.authorM Y Park-
dc.contributor.authorE J Seo-
dc.contributor.authorH W Yoo-
dc.contributor.authorI S Park-
dc.contributor.authorB Oh-
dc.contributor.authorJ K Lee-
dc.date.accessioned2017-04-19T09:13:11Z-
dc.date.available2017-04-19T09:13:11Z-
dc.date.issued2008-
dc.identifier.issnI000-0158-
dc.identifier.uri10.5808/GI.2008.6.4.173ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/8823-
dc.description.abstractThe human genome has evolved as a consequence of evolutionary forces, such as natural selection. In this study, we investigated natural selection on the human genes by comparing the numbers of nonsynonymous (NS) and synonymous (S) mutations in individual genes. We initially collected all coding SNP data of all human genes from the public dbSNP. Among the human genes, we selected 3 different selection groups of genes: positively selected genes (NS/S≥3), negatively selected genes (NS/S≤1/3) and neutral selection genes (0.9<NS/S<1.1). We characterized human genes targeted by natural selection. Negatively selected human genes were markedly associated with disease occurrence, but not positively selected genes. Interestingly, positively selected genes displayed an increase in potentially deleterious nonsynonymous SNPs with an increased frequency of tryptophan and tyrosine residues, suggesting a correlation with protective effects against human disease. Furthermore, our nonsynonymous/synonymous ratio data imply that specific human genes, such as ALMS1 and SPTBN5 genes, are differentially selected among distinct populations. We confirmed that inferences of natural selection using the NS/S ratio can be used extensively to identify functional genes selected during the evolutionary adaptation process.-
dc.publisherKorea Soc-Assoc-Inst-
dc.titleIdentification and characterization of human genes targeted by natural selection = 자연선택에 의한 인간유전자의 변이 특성화 연구-
dc.title.alternativeIdentification and characterization of human genes targeted by natural selection-
dc.typeArticle-
dc.citation.titleGenomics & Informatics-
dc.citation.number4-
dc.citation.endPage180-
dc.citation.startPage173-
dc.citation.volume6-
dc.contributor.affiliatedAuthorYoung Joo Kim-
dc.contributor.alternativeName유하정-
dc.contributor.alternativeName김영주-
dc.contributor.alternativeName박영규-
dc.contributor.alternativeName김재정-
dc.contributor.alternativeName박미영-
dc.contributor.alternativeName서을주-
dc.contributor.alternativeName유한욱-
dc.contributor.alternativeName박인숙-
dc.contributor.alternativeName오범석-
dc.contributor.alternativeName이종극-
dc.identifier.bibliographicCitationGenomics & Informatics, vol. 6, no. 4, pp. 173-180-
dc.identifier.doi10.5808/GI.2008.6.4.173-
dc.subject.keywordsingle nucleotide polymorphism (SNP)-
dc.subject.keywordnatural selection-
dc.subject.keyworddisease genes-
dc.subject.keywordethnicity-
dc.subject.localSingle Nucleotide Polymorphism-
dc.subject.localsingle nucleotide polymorphism-
dc.subject.localsingle nucleotide polymorphism (SNP)-
dc.subject.localSingle nucleotide polymorphisms (SNPs)-
dc.subject.localSingle-nucleotide polymorphism-
dc.subject.localSingle nucleotide polymorphism-
dc.subject.localSingle nucleotide polymorphisms-
dc.subject.localsingle-nucleotide polymorphism-
dc.subject.localSingle nucleotide polymorphism (SNP)-
dc.subject.localnatural selection-
dc.subject.localdisease gene-
dc.subject.localdisease genes-
dc.subject.localEthnicity-
dc.subject.localethnicity-
dc.description.journalClassN-
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