Hypoxia-inducible factor-1 inhibitory benzofurans and chalcone-derived diels-alder adducts from Morus species

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dc.contributor.authorN T Dat-
dc.contributor.authorX Jin-
dc.contributor.authorKyeong Lee-
dc.contributor.authorYoung-Soo Hong-
dc.contributor.authorY H Kim-
dc.contributor.authorJung Joon Lee-
dc.date.accessioned2017-04-19T09:13:12Z-
dc.date.available2017-04-19T09:13:12Z-
dc.date.issued2009-
dc.identifier.issn01633864-
dc.identifier.uri10.1021/np800491uko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/8830-
dc.description.abstractHypoxia-inducible factor-1 (HIF-1) is the central mediator of cellular responses to low oxygen concentrations and vital to many aspects of cancer biology. Bioassay-guided fractionation of the chloroform-soluble extracts of Morus species using a hypoxia response element (HRE)-dependent reporter assay led to identification of six benzofurans (1-6) and two chalcone-derived Diels-Alder adducts (7, 8) from Mori Cortex Radicis and three prenylated benzofurans (9-11) and four chalcone-derived Diels-Alder adducts (12-15) from Morus bombycis. The structure of the new 2-arylbenzofuran-type compound, moracin Q (3), was elucidated by spectroscopic methods, and the absolute configuration of 2 was determined for the first time. The selected compounds (1-3, 5, 7, 9, 10, and 12) from the cell-based reporter assay were found to inhibit hypoxia-induced HIF-1α accumulation in a dose-dependent manner in human hepatocelluar carcinoma cell-line Hep3B cells. Furthermore, these compounds were also active against hypoxia-induced vascular endothelial growth factor (VEGF) secretion in Hep3B cells.-
dc.publisherAmer Chem Soc-
dc.titleHypoxia-inducible factor-1 inhibitory benzofurans and chalcone-derived diels-alder adducts from Morus species-
dc.title.alternativeHypoxia-inducible factor-1 inhibitory benzofurans and chalcone-derived diels-alder adducts from Morus species-
dc.typeArticle-
dc.citation.titleJournal of Natural Products-
dc.citation.number1-
dc.citation.endPage43-
dc.citation.startPage39-
dc.citation.volume72-
dc.contributor.affiliatedAuthorYoung-Soo Hong-
dc.contributor.alternativeNameDat-
dc.contributor.alternativeNameJin-
dc.contributor.alternativeName이경-
dc.contributor.alternativeName홍영수-
dc.contributor.alternativeName김영호-
dc.contributor.alternativeName이정준-
dc.identifier.bibliographicCitationJournal of Natural Products, vol. 72, no. 1, pp. 39-43-
dc.identifier.doi10.1021/np800491u-
dc.description.journalClassY-
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Ochang Branch Institute > Anticancer Agent Research Center > 1. Journal Articles
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