Upregulation and secretion of macrophage inhibitory cytokine-1 (MIC-1) in gastric cancers

Cited 34 time in scopus
Metadata Downloads
Title
Upregulation and secretion of macrophage inhibitory cytokine-1 (MIC-1) in gastric cancers
Author(s)
Kyoung Eun Baek; Suk Ran YoonJong-Tae Kim; K S Kim; S H Kang; Y Yang; J S Lim; In Pyo Choi; M S Nam; M Yoon; Hee Gu Lee
Bibliographic Citation
Clinica Chimica Acta, vol. 401, no. 1, pp. 128-133
Publication Year
2009
Abstract
Background: Macrophage inhibitory cytokine-1 (MIC-1), a distant member of the transforming growth factor (TGF)-β superfamily, has been reported to be upregulated and secreted from several cancers. We examined MIC-1 expression and secretion in gastric cancers. Methods: MIC-1 mRNA and protein levels in cancer tissues and cell lines were analyzed by RT-PCR and Western blot. MIC-1 expression in cancer tissues and its secretion in serum were analyzed using immunohistochemistry and ELISA. Results: MIC-1 was significantly upregulated in gastric cancer tissues and cell lines. MIC-1 was secreted from gastric SNU620 cells and its levels in the serum of cancer patients were 10-fold higher than those of healthy controls. In addition, the staining of MIC-1 expression was strongly increased in metastatic gastric cancers. Conclusions: MIC-1 was obviously overexpressed in gastric cancers and MIC-1 secretion into blood may be useful for the prediction of gastric cancer progression.
Keyword
gastric cancerGDF-15growth differentiation factor-15macrophage-inhibitory cytokine-1MIC-1
ISSN
0009-8981
Publisher
Elsevier
DOI
http://dx.doi.org/10.1016/j.cca.2008.12.008
Type
Article
Appears in Collections:
Division of Biomedical Research > Immunotherapy Research Center > 1. Journal Articles
Files in This Item:
  • There are no files associated with this item.


Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.