Identification and molecular characterization of PERV gamma1 long terminal repeats = PERV gamma1 LTR의 동정과 분자적인 특성 규명

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dc.contributor.authorJae Won Huh-
dc.contributor.authorDae Soo Kim-
dc.contributor.authorH S Ha-
dc.contributor.authorK Ahn-
dc.contributor.authorKyu Tae Chang-
dc.contributor.authorB W Cho-
dc.contributor.authorH S Kim-
dc.date.accessioned2017-04-19T09:13:14Z-
dc.date.available2017-04-19T09:13:14Z-
dc.date.issued2009-
dc.identifier.issn1016-8478-
dc.identifier.uri10.1007/s10059-009-0013-3ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/8845-
dc.description.abstractPorcine endogenous retroviruses (PERVs) gamma1 in the pig genome have the potential to act as harmful factors in xenotransplantation (pig-to-human). Long terminal repeats (LTRs) are known to be strong promoter elements that could control the transcription activity of PERV elements and the adjacent functional genes. To investigate the transcribed PERV gamma1 LTR elements in pig tissues, bioin-formatic and experimental approaches were conducted. Using RT-PCR amplification and sequencing approaches, 69 different transcribed LTR elements were identified. And 69 LTR elements could be divided into six groups (15 subgroups) by internal variation including tandem repeated sequences, insertion and deletion (INDEL). Remarkably, all internal variations were indentified in U3 region of LTR elements. Taken together, the identification and characterization of various PERV LTR transcripts allow us to extend our knowledge of PERV and its transcriptional study.-
dc.publisherKorea Soc-Assoc-Inst-
dc.titleIdentification and molecular characterization of PERV gamma1 long terminal repeats = PERV gamma1 LTR의 동정과 분자적인 특성 규명-
dc.title.alternativeIdentification and molecular characterization of PERV gamma1 long terminal repeats-
dc.typeArticle-
dc.citation.titleMolecules and Cells-
dc.citation.number1-
dc.citation.endPage123-
dc.citation.startPage119-
dc.citation.volume27-
dc.contributor.affiliatedAuthorJae Won Huh-
dc.contributor.affiliatedAuthorDae Soo Kim-
dc.contributor.affiliatedAuthorKyu Tae Chang-
dc.contributor.alternativeName허재원-
dc.contributor.alternativeName김대수-
dc.contributor.alternativeName하홍석-
dc.contributor.alternativeName안궁-
dc.contributor.alternativeName장규태-
dc.contributor.alternativeName조병욱-
dc.contributor.alternativeName김희수-
dc.identifier.bibliographicCitationMolecules and Cells, vol. 27, no. 1, pp. 119-123-
dc.identifier.doi10.1007/s10059-009-0013-3-
dc.subject.keywordBioinformatics-
dc.subject.keywordLTR element-
dc.subject.keywordPERV-
dc.subject.keywordPig-
dc.subject.keywordXenotransplantation-
dc.subject.localBioinformatics-
dc.subject.localbioinformatics-
dc.subject.localBioinfromatics-
dc.subject.localBioinformratics-
dc.subject.localBioinformatibs-
dc.subject.localLTR element-
dc.subject.localLTR elements-
dc.subject.localPERV-
dc.subject.localPig-
dc.subject.localPigs-
dc.subject.localpig-
dc.subject.localpigs-
dc.subject.localxenotransplantation-
dc.subject.localXenotransplantation-
dc.description.journalClassY-
Appears in Collections:
Ochang Branch Institute > Division of National Bio-Infrastructure > National Primate Research Center > 1. Journal Articles
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