Antiatherosclerotic effects of Artemisia princeps Pampanini cv.Sajabal in LDL receptor deficient mice = LDL receptor 결핍마우스에서 사자발쑥의 항동맥경화효과

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Title
Antiatherosclerotic effects of Artemisia princeps Pampanini cv.Sajabal in LDL receptor deficient mice = LDL receptor 결핍마우스에서 사자발쑥의 항동맥경화효과
Author(s)
Jong-Min Han; M J Kim; Seung Hwa Baek; S An; Y Y Jin; H G Chung; N I Baek; M S Choi; K T Lee; Tae Sook Jeong
Bibliographic Citation
Journal of Agricultural and Food Chemistry, vol. 57, no. 4, pp. 1267-1274
Publication Year
2009
Abstract
Antiatherosclerotic effects of ethanolic extracts of Artemisia princeps Pampanini cv. Sajabal (ESJ) were investigated in low-density lipoprotein receptor deficient (LDLR -/-) mice. The Western dietinduced high levels of total cholesterol and triglyceride were similar in the ESJ and control groups. However, circulating oxidized LDL was significantly decreased in the ESJ group (p < 0.05). ESJ also markedly decreased aortic expression levels of intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), tumor necrosis factor-α (TNF-α), and interleukin-1β (IL-1β), and reduced the aortic lesion formation and macrophage accumulation by 36.7% (p < 0.05) and 43% (p < 0.01) in the control group, respectively. Additionally, ESJ inhibited atherogenic properties with cytokine-induced surface expression of cell adhesion molecules, chemokines, and monocyte adhesion to the human umbilical vein endothelial cells (HUVECs), and simultaneously suppressed nuclear factor-κB (NF-κB) activation. These results suggest that ethanolic extracts of Artemisia princeps Pampanini cv. Sajabal contributes to the antiatherosclerotic and anti-inflammatory activities in LDLR -/- mice.
Keyword
artemisia princeps pamp. cvatherosclerosisinflammationNF-κBoxidized LDLsajabal
ISSN
0021-8561
Publisher
Amer Chem Soc
DOI
http://dx.doi.org/10.1021/jf802639y
Type
Article
Appears in Collections:
Division of Biomaterials Research > Industrial Bio-materials Research Center > 1. Journal Articles
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