Genistein-derivatives from Tetracera scandens stimulate glucose-uptake in L6 myotubes

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dc.contributor.authorMyung Sun Lee-
dc.contributor.authorChung-Hee Kim-
dc.contributor.authorD M Hoang-
dc.contributor.authorBo Yeon Kim-
dc.contributor.authorC B Sohn-
dc.contributor.authorM R Kim-
dc.contributor.authorJong Seog Ahn-
dc.date.accessioned2017-04-19T09:13:18Z-
dc.date.available2017-04-19T09:13:18Z-
dc.date.issued2009-
dc.identifier.issn0918-6158-
dc.identifier.uri10.1248/bpb.32.504ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/8851-
dc.description.abstractAn EtOAc-soluble partition of the MeOH extract of a branch of Tetracera scandens (Dilleniaceae family) was subjected to a glucose-uptake assay, which led to the isolation and identification of five isoflavones of previously known structure namely, genistein (1), its derivatives 3′,5′- diprenylgenistein (2), 6,8-diprenylgenistein (3), derrone (4) and alpinumisoflavone (5). of these, compounds 2-5 exhibited significant glucose-uptake activity in basal and insulin-stimulated L6 myotubes. The findings from adenosine monophosphate-activated kinase (AMPK) activation and glucose transport protein4 (GLUT4) and GLUT1 over-expression revealed certain characteristics of compounds 2-5. These compounds inhibited protein tyrosine phosphatase 1B (PTP1B) activities with IC50 values ranging from 20.63±0.17 to 37.52±0.31 μM. No muscle cell toxicity was reported with compounds 3-5, while compounds 1 and 2 reduced muscle cell viability with IC50 values of 34.27±0.35 and 18.69±0.19 μM, respectively. It was concluded that T. scandens and its constituents exerted highly desirable activities on type 2 diabetes mellitus treatment since they significantly stimulated the uptake of glucose, AMPK phosphorylation, GLUT4 and GLUT1 mRNA expressions and PTP1B inhibition in L6 myotubes.-
dc.publisherPharmaceutical Soc Japan-
dc.titleGenistein-derivatives from Tetracera scandens stimulate glucose-uptake in L6 myotubes-
dc.title.alternativeGenistein-derivatives from Tetracera scandens stimulate glucose-uptake in L6 myotubes-
dc.typeArticle-
dc.citation.titleBiological & Pharmaceutical Bulletin-
dc.citation.number3-
dc.citation.endPage508-
dc.citation.startPage504-
dc.citation.volume32-
dc.contributor.affiliatedAuthorMyung Sun Lee-
dc.contributor.affiliatedAuthorBo Yeon Kim-
dc.contributor.affiliatedAuthorJong Seog Ahn-
dc.contributor.alternativeName이명선-
dc.contributor.alternativeName김청희-
dc.contributor.alternativeNameHoang-
dc.contributor.alternativeName김보연-
dc.contributor.alternativeName손천배-
dc.contributor.alternativeName김미리-
dc.contributor.alternativeName안종석-
dc.identifier.bibliographicCitationBiological & Pharmaceutical Bulletin, vol. 32, no. 3, pp. 504-508-
dc.identifier.doi10.1248/bpb.32.504-
dc.subject.keywordDiabetes-
dc.subject.keywordGlucose-uptake-
dc.subject.keywordIsoflavone-
dc.subject.keywordL6 myotube-
dc.subject.keywordTetracera scandens-
dc.subject.localDiabetes-
dc.subject.localdiabetes-
dc.subject.localGlucose uptake-
dc.subject.localglucose uptake-
dc.subject.localGlucose-uptake-
dc.subject.localIsoflavone-
dc.subject.localIsoflavones-
dc.subject.localL6 myotube-
dc.subject.localTetracera scandens-
dc.description.journalClassY-
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Ochang Branch Institute > Chemical Biology Research Center > 1. Journal Articles
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