Signal crosstalk between estrogen and peroxisome proliferator-activated receptor alpha on adiposity

Cited 11 time in scopus
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Title
Signal crosstalk between estrogen and peroxisome proliferator-activated receptor alpha on adiposity
Author(s)
B H Kim; Young Suk Won; D Y Kim; B Kim; E Y Kim; M Yoon; G T Oh
Bibliographic Citation
BMB Reports, vol. 42, no. 2, pp. 91-95
Publication Year
2009
Abstract
Peroxisome proliferator-activated receptor alpha and estrogen are believed to be involved in metabolic changes leading to obesity. To test this relationship, we divided female wildtype and PPAR alpha-deficient mice fed on a high fat diet into the following groups: mock-operated, ovariectomized (OVX), and E(2)-treated. The visceral white adipose tissue and plasma cholesterol levels were increased significantly in wild type OVX and decreased in the E(2)-treated group, but interestingly not in PPAR alpha-deficient mice. The mRNA levels of lipoprotein lipase in adipose tissue were also increased in only wild type OVX and decreased significantly in E(2)-treated mice. These novel results suggest the possibility of signaling crosstalk between PPAR alpha and E2, causing obesity in vivo.
Keyword
EstrogenLPLObesityPPARαSignaling crosstalk
ISSN
1225-8687
Publisher
Korea Soc-Assoc-Inst
DOI
http://dx.doi.org/10.5483/BMBRep.2009.42.2.091
Type
Article
Appears in Collections:
Ochang Branch Institute > Division of National Bio-Infrastructure > Laboratory Animal Resource & Research Center > 1. Journal Articles
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