Synthesis and cytotoxic activities of C-benzylated flavonoids

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dc.contributor.authorY J Choi-
dc.contributor.authorHwan Mook Kim-
dc.contributor.authorH D Kim-
dc.date.accessioned2017-04-19T09:13:19Z-
dc.date.available2017-04-19T09:13:19Z-
dc.date.issued2009-
dc.identifier.issn0253-6269-
dc.identifier.uri10.1007/s12272-009-1118-0ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/8863-
dc.description.abstractSome C-benzylated flavonoids based on gericudranin A were synthesized and evaluated their cytotoxic activities for the elucidation of structure-activity relationship. 2,4,6-Trihydroxyacetophenone was converted to target molecules in 67 steps via sequential protection, aldol condensation, cyclization, regioselective C-benzylation, and deprotection. The cellular growth inhibition of the synthetic C-benzylated flavonoids was investigated against sixteen human cancer cell lines. Among these compounds, 5b showed the most potent cytotoxicities against several cell lines, especially as potent as adriamycin against SNB19 cell lines with an IC50 value of 0.7 μM.-
dc.publisherPharmaceutical Soc Korea-
dc.titleSynthesis and cytotoxic activities of C-benzylated flavonoids-
dc.title.alternativeSynthesis and cytotoxic activities of C-benzylated flavonoids-
dc.typeArticle-
dc.citation.titleArchives of Pharmacal Research-
dc.citation.number1-
dc.citation.endPage63-
dc.citation.startPage59-
dc.citation.volume32-
dc.contributor.affiliatedAuthorHwan Mook Kim-
dc.contributor.alternativeName최윤정-
dc.contributor.alternativeName김환묵-
dc.contributor.alternativeName김희두-
dc.identifier.bibliographicCitationArchives of Pharmacal Research, vol. 32, no. 1, pp. 59-63-
dc.identifier.doi10.1007/s12272-009-1118-0-
dc.subject.keywordC-benzylated flavonoid-
dc.subject.keywordcytotoxicity-
dc.subject.keywordgericudranin A-
dc.subject.keywordSAR-
dc.subject.keywordsynthesis-
dc.subject.localC-benzylated flavonoid-
dc.subject.localCytotoxicity-
dc.subject.localcytotoxicity-
dc.subject.localgericudranin A-
dc.subject.localSAR (structure-activity relationship)-
dc.subject.localSAR-
dc.subject.localsynthesis-
dc.subject.localSynthesis-
dc.subject.localsynthesis (chemical)-
dc.description.journalClassY-
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