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- Diacylglycerol acyltransferase-inhibitory compounds from Erythrina senegalensis
- W K Oh; Chul Ho Lee; J H Seo; M Y Chung; L Cui; T Fomum; J S Kang; Hyun Sun Lee
- Bibliographic Citation
- Archives of Pharmacal Research, vol. 32, no. 1, pp. 43-47
- Publication Year
- Inhibition of acyl CoA:diacylglycerol acyltransferase (DGAT) is proposed to be a drug target for the treatment of obesity and type 2 diabetes. Bioassay-guided fractionation of the CH2Cl2-soluble extract of the stem bark of Erythrina senegalensis, using an in vitro DGAT enzyme assay, resulted in the isolation of eight known prenylflavonoids, 8-prenylleutone (1), auriculatin (2), erysenegalensein O (3), erysenegalensein D (4), erysenegalensein N (5), derrone (6), alpinumisoflavone (7), and 6,8-diprenylgenistein (8). Compounds 1, 2-4, 6, and 8 inhibited DGAT activity, with IC50 values ranging from 1.1 ± 0.3 to 15.1 ± 1.1 μg/mL. On the basis of the data obtained, we propose isoflavonoids with isoprenyl groups as a novel class of DGAT inhibitors.
- Diacylglycerol acyltransferase; Erythrina senegalensis; Prenylflavonoid
- Pharmaceutical Soc Korea
- Appears in Collections:
- Ochang Branch Institute > Division of Bioinfrastructure > Laboratory Animal Resource Center > 1. Journal Articles
Ochang Branch Institute > Natural Medicine Research Center > 1. Journal Articles
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