Diacylglycerol acyltransferase-inhibitory compounds from Erythrina senegalensis

Cited 18 time in scopus
Metadata Downloads
Title
Diacylglycerol acyltransferase-inhibitory compounds from Erythrina senegalensis
Author(s)
W K Oh; Chul Ho Lee; J H Seo; M Y Chung; L Cui; T Fomum; J S Kang; Hyun Sun Lee
Bibliographic Citation
Archives of Pharmacal Research, vol. 32, no. 1, pp. 43-47
Publication Year
2009
Abstract
Inhibition of acyl CoA:diacylglycerol acyltransferase (DGAT) is proposed to be a drug target for the treatment of obesity and type 2 diabetes. Bioassay-guided fractionation of the CH2Cl2-soluble extract of the stem bark of Erythrina senegalensis, using an in vitro DGAT enzyme assay, resulted in the isolation of eight known prenylflavonoids, 8-prenylleutone (1), auriculatin (2), erysenegalensein O (3), erysenegalensein D (4), erysenegalensein N (5), derrone (6), alpinumisoflavone (7), and 6,8-diprenylgenistein (8). Compounds 1, 2-4, 6, and 8 inhibited DGAT activity, with IC50 values ranging from 1.1 ± 0.3 to 15.1 ± 1.1 μg/mL. On the basis of the data obtained, we propose isoflavonoids with isoprenyl groups as a novel class of DGAT inhibitors.
Keyword
Diacylglycerol acyltransferaseErythrina senegalensisPrenylflavonoid
ISSN
0253-6269
Publisher
Pharmaceutical Soc Korea
DOI
http://dx.doi.org/10.1007/s12272-009-1116-2
Type
Article
Appears in Collections:
Ochang Branch Institute > Division of Bioinfrastructure > Laboratory Animal Resource Center > 1. Journal Articles
Ochang Branch Institute > Natural Medicine Research Center > 1. Journal Articles
Files in This Item:
  • There are no files associated with this item.


Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.