Identification of candidate SNP (single nucleotide polymorphism) for growth and carcass traits related to QTL on chromosome 6 in Hanwoo (Korean cattle)

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Title
Identification of candidate SNP (single nucleotide polymorphism) for growth and carcass traits related to QTL on chromosome 6 in Hanwoo (Korean cattle)
Author(s)
Y S Lee; J H Lee; J Y Lee; J J Kim; Hong-Seog Park; J S Yeo
Bibliographic Citation
Asian-Australasian Journal of Animal Sciences, vol. 21, no. 12, pp. 1703-1709
Publication Year
2008
Abstract
As genetic markers, single nucleotide polymorphisms (SNP) are very appropriate for the development of genetic tests for economic traits in livestock. Several microsatellite markers have been identified as useful markers for the genetic improvement of Hanwoo. Among those markers, ILSTS035 was recently mapped at a similar position with four SNPs (AH1_11, AH1_9, 31465_446, and 12273_165) in a linkage map of EST-based SNP in BAT6. Among the four SNPs, two SNPs (31465_446 and 12273J65) were analyzed using BLAST at the NCBI web site. The sequences including the 12273_165 SNP were identified at the intron region within the LOC534614 gene on the gene sequence map (Bos taurus NCBI Map view, build 3.1). The LOC534614 gene represents a protein similar to myosin heavy chain, fat skeletal muscle, embryonic isoform 1 in the dog, and myosin_l (Myosin heavy chain D) in Macaco mulatta. In cattle, the myosin heavy chain was associated with muscle development. The phenotypic data for growth and carcass traits in the 415 animals were analyzed by the mixed ANCOVA (analysis of covariance) linear model using PROC GLM module in SAS v9.1. By the genotyping of Hanwoo individuals (n = 415) to evaluate the association of SNP with growth and carcass traits, it was shown that the 12273_165 SNP region within LOC534614 may be a candidate marker for growth. The results of the statistical analyses suggested that the genotype of the 12273_165 SNP significantly affected birth weight, weight of the cattle at 24 months of age, average daily gain and carcass cold weight (p<0.05). Consequently, the 12273_165 SNP polymorphisms at the LOC534614 gene may be associated with growth in Hanwoo, and functional validation of polymorphisms in LOC534614 should be performed in the future.
Keyword
BTA6growthhanwooQTLSNP
ISSN
1011-2367
Publisher
Asian-Australasian Assoc Animal Production Soc
DOI
http://dx.doi.org/10.5713/ajas.2008.80223
Type
Article
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1. Journal Articles > Journal Articles
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