Increased -1 ribosomal frameshifting efficiency by yeast prion-like phenotype [PSI+]

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Title
Increased -1 ribosomal frameshifting efficiency by yeast prion-like phenotype [PSI+]
Author(s)
H J Park; S J Park; Doo-Byoung Oh; S Lee; Y G Kim
Bibliographic Citation
FEBS Letters, vol. 583, no. 4, pp. 665-669
Publication Year
2009
Abstract
Programmed -1 ribosomal frameshifting (-1RF) is usually regulated by a slippery sequence and an RNA secondary structure but can be affected by the slippery sequence combined with translational perturbation. Dramatic increases of -1RF efficiencies arise from the slippery sequences in [PSI+], an epigenetic modifier of translation termination fidelity. Curing of [PSI+] abolished such increases of -1RF efficiency. Enhanced -1RF frequency at the slippery sequences could be another physiological effect induced directly or indirectly by the perturbation of the translation process in [PSI+] cells.
ISSN
0014-5793
Publisher
Wiley
DOI
http://dx.doi.org/10.1016/j.febslet.2009.01.015
Type
Article
Appears in Collections:
Aging Convergence Research Center > 1. Journal Articles
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