Plasma pharmacokinetics and metabolism of the antitumour drug candidate 2'-benzoyloxycinnamaldehyde in rats

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Title
Plasma pharmacokinetics and metabolism of the antitumour drug candidate 2'-benzoyloxycinnamaldehyde in rats
Author(s)
Kiho Lee; Byoung-Mog Kwon; Kang Jeon Kim; J Ryu; Soo Jin Oh; Kye Sook Lee; M G Kwon; Song Kyu Park; Jong Soon KangChang Woo Lee; Hwan Mook Kim
Bibliographic Citation
Xenobiotica, vol. 39, no. 3, pp. 255-265
Publication Year
2009
Abstract
The pharmacokinetics and metabolism of 2'-benzoyloxycinnamaldehyde (BCA) was characterized in male Sprague-Dawley rats as part of the preclinical evaluations for developing this compound as an antitumour agent. BCA was not detected in the plasma following either intravenous or oral dose, whereas its putative metabolites 2'-hydroxycinnamaldehyde (HCA) and o-coumaric acid were present at considerable levels. In separate pharmacokinetics studies, HCA exhibited a high systemic clearance and a large volume of distribution, whereas both pharmacokinetic parameters were much lower for o-coumaric acid. The terminal half-life of both metabolites was approximately 2 h. BCA was converted rapidly to HCA in rat serum, liver microsomes and cytosol in vitro; HCA was subsequently converted to o-coumaric acid in a quantitative manner only in the liver cytosol. In addition, the formation of o-coumaric acid was inhibited significantly by menadione, a specific inhibitor for aldehyde oxidase. Taken collectively, the results suggest that the rapid systemic clearance of HCA is likely due mainly to hepatic clearance occurring from aldehyde oxidase-catalysed biotransformation to o- coumaric acid. In conclusion, the present work demonstrates that the anticancer drug candidate BCA is highly likely to work as its active metabolite HCA in the body.
Keyword
2'-Benzoyloxycinnamaldehyde2'-hydroxycinnamaldehydeActive metaboliteAnticancerAntitumourDrug metabolismO-coumaric acidPharmacokinetics
ISSN
0049-8254
Publisher
T&F (Taylor & Francis)
DOI
http://dx.doi.org/10.1080/00498250802650069
Type
Article
Appears in Collections:
Division of Biomedical Research > Genome Editing Research Center > 1. Journal Articles
Ochang Branch Institute > Division of Bioinfrastructure > Laboratory Animal Resource Center > 1. Journal Articles
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