VDUP1 potentiates Ras-mediated angiogenesis via ROS production in endothelial cells

Cited 10 time in scopus
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Title
VDUP1 potentiates Ras-mediated angiogenesis via ROS production in endothelial cells
Author(s)
Z H Piao; Suk Ran Yoon; M S Kim; J H Jeon; S H Lee; Tae-Don KimHee Gu LeeKwang-Hee Bae; J K Min; Sang Jeon Chung; Moonil KimYeesook ChoDoo-Byoung Oh; S Y Park; J W Chung; In Pyo Choi
Bibliographic Citation
Cellular and Molecular Biology, vol. 55, no. Suppl, pp. 1096-1103
Publication Year
2009
Abstract
Vitamin D3 up-regulated protein 1 (VDUP1) is a tumor suppressor of which expression is reduced in a variety of cancer cells, and enforced expression inhibits the tumor cell proliferation. It inhibits the activity of thioredoxin, thus contributing cellular ROS generation. Since ROS is a critical factor for angiogenesis, we investigated the role of VDUP1 in angiogenesis and endothelial proliferation. The expression of VDUP1 was upregulated by overexpression of an oncogene, Ras. Enforced expression of VDUP1 increases ROS production and proliferation of Ras-overexpressing endothelial cells. Overexpression of VDUP1 increases the resistance to the anchorage-dependent cell death and tube formation of the Ras-overexpressing endothelial cell. In addition, the removal of ROS by ROS scavenger attenuates the effect of VDUP1 on tube formation. These results suggest that VDUP1 is involved in Ras-mediated angiogenesis via ROS generation in endothelial cells.
Keyword
AngiogenesisAnoikisRasROSVDUP1
ISSN
0145-5680
Publisher
C M B Assoc
DOI
http://dx.doi.org/10.1170/125
Type
Article
Appears in Collections:
Division of Biomedical Research > Immunotherapy Research Center > 1. Journal Articles
Division of Biomedical Research > Metabolic Regulation Research Center > 1. Journal Articles
Division of Biomedical Research > Biotherapeutics Translational Research Center > 1. Journal Articles
Critical Diseases Diagnostics Convergence Research Center > 1. Journal Articles
Aging Convergence Research Center > 1. Journal Articles
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