Improvement in antigen-delivery using fabrication of a grooves-embedded microneedle array

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dc.contributor.authorM Han-
dc.contributor.authorD K Kim-
dc.contributor.authorS H Kang-
dc.contributor.authorHyo Ran Yoon-
dc.contributor.authorBo Yeon Kim-
dc.contributor.authorS S Lee-
dc.contributor.authorK D Kim-
dc.contributor.authorHee Gu Lee-
dc.date.accessioned2017-04-19T09:13:26Z-
dc.date.available2017-04-19T09:13:26Z-
dc.date.issued2009-
dc.identifier.issn0925-4005-
dc.identifier.uri10.1016/j.snb.2008.11.017ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/8880-
dc.description.abstractThe skin, which has immunocompetent cells, is an attractive target for vaccine delivery. Intradermal immunization is the most effective immunization, though it requires considerable technical skill. A promising approach to intradermal immunization is microneedle array technology. This paper presents a new fabrication method for grooves-embedded microneedle arrays of a bio-compatible polymer and the immunization characteristics to ovalbumin delivered into mice by the microneedle arrays through the skin. The microneedles fabricated using a hot embossing process have a three-dimensional sharp tip, smooth or grooves-embedded shafts, and large bases. The height, base width, and thickness are 880 ± 20, 710 ± 15, and 145 ± 15 μm, respectively. To perform an immune response test, the ovalbumin-coated microneedle arrays were inserted into mouse skin and then, the titer of antibody to ovalbumin was analyzed. The increased number and deeper grooves of the microneedle induced a higher antibody response. These results suggest that the grooves-embedded microneedle array is loaded with more antigens than the smooth one and that the antigens are well delivered into the skin, though they are located on the deep grooves of the microneedles. In summary, the fabrication of grooves-embedded microneedles can supply an improved tool for intradermal immunization.-
dc.publisherElsevier-
dc.titleImprovement in antigen-delivery using fabrication of a grooves-embedded microneedle array-
dc.title.alternativeImprovement in antigen-delivery using fabrication of a grooves-embedded microneedle array-
dc.typeArticle-
dc.citation.titleSensors and Actuators B-Chemical-
dc.citation.number1-
dc.citation.endPage280-
dc.citation.startPage274-
dc.citation.volume137-
dc.contributor.affiliatedAuthorHyo Ran Yoon-
dc.contributor.affiliatedAuthorBo Yeon Kim-
dc.contributor.affiliatedAuthorHee Gu Lee-
dc.contributor.alternativeName한만희-
dc.contributor.alternativeName김대광-
dc.contributor.alternativeName강성호-
dc.contributor.alternativeName윤효란-
dc.contributor.alternativeName김보연-
dc.contributor.alternativeName이승-
dc.contributor.alternativeName김광동-
dc.contributor.alternativeName이희구-
dc.identifier.bibliographicCitationSensors and Actuators B-Chemical, vol. 137, no. 1, pp. 274-280-
dc.identifier.doi10.1016/j.snb.2008.11.017-
dc.subject.keywordDrug delivery system (DDS)-
dc.subject.keywordIntradermal immunization-
dc.subject.keywordOvalbumin-
dc.subject.keywordVaccination-
dc.subject.localDrug delivery system-
dc.subject.localDrug delivery system (DDS)-
dc.subject.localIntradermal immunization-
dc.subject.localOvalbumin-
dc.subject.localOvalbumin (OVA)-
dc.subject.localovalbumin-
dc.subject.localVaccination-
dc.subject.localvaccination-
dc.description.journalClassY-
Appears in Collections:
Ochang Branch Institute > Chemical Biology Research Center > 1. Journal Articles
Division of Biomedical Research > Immunotherapy Research Center > 1. Journal Articles
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