Obovatol isolated from Magnolia obovata enhances pentobarbital-induced sleeping time: Possible involvement of GABA(A) receptors/chloride channel activation = 오보바톨의 수면 개선 효과

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dc.contributor.authorH Ma-
dc.contributor.authorY J Jo-
dc.contributor.authorY Ma-
dc.contributor.authorJ T Hong-
dc.contributor.authorByoung-Mog Kwon-
dc.contributor.authorK W Oh-
dc.date.accessioned2017-04-19T09:13:26Z-
dc.date.available2017-04-19T09:13:26Z-
dc.date.issued2009-
dc.identifier.issn09447113-
dc.identifier.uri10.1016/j.phymed.2008.12.007ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/8881-
dc.description.abstractThis study aimed to investigate the effects of obovatol isolated from Magnolia obovata on pentobarbital-induced sleeping behaviors and to determine whether these effects were mediated by GABAA receptors/chloride channel activation, using a western blot technique and Cl- sensitive fluorescence probe. GABAA receptors subunits expression and chloride influx were investigated in cultured cerebellar granule cells. Obovatol (0.05, 0.1, and 0.2 mg/kg) prolonged the sleeping time induced by pentobarbital (42 mg/kg). In addition, obovatol (20 and 50 μM) significantly increased Cl- influx in the primary cultured cerebellar granule cells. Moreover, obovatol increased the expression of GABAA receptor α-, β-, and γ-subunits. However, it had no effect on the abundance of the expression of glutamic acid decarboxylase (GAD), suggesting that obovatol might not activate GAD. These results suggest that obovatol potentiates pentobarbital-induced sleeping time through the GABAA receptors/chloride channel activation.-
dc.publisherElsevier-
dc.titleObovatol isolated from Magnolia obovata enhances pentobarbital-induced sleeping time: Possible involvement of GABA(A) receptors/chloride channel activation = 오보바톨의 수면 개선 효과-
dc.title.alternativeObovatol isolated from Magnolia obovata enhances pentobarbital-induced sleeping time: Possible involvement of GABA(A) receptors/chloride channel activation-
dc.typeArticle-
dc.citation.titlePhytomedicine-
dc.citation.number4-
dc.citation.endPage313-
dc.citation.startPage308-
dc.citation.volume16-
dc.contributor.affiliatedAuthorByoung-Mog Kwon-
dc.contributor.alternativeName마홍-
dc.contributor.alternativeName조영준-
dc.contributor.alternativeName마윤-
dc.contributor.alternativeName홍진태-
dc.contributor.alternativeName권병목-
dc.contributor.alternativeName오기완-
dc.identifier.bibliographicCitationPhytomedicine, vol. 16, no. 4, pp. 308-313-
dc.identifier.doi10.1016/j.phymed.2008.12.007-
dc.subject.keywordChloride influx-
dc.subject.keywordGABAA receptors-
dc.subject.keywordGlutamic acid decarboxylase (GAD)-
dc.subject.keywordMagnolia obovata-
dc.subject.keywordObovatol-
dc.subject.keywordPentobarbital-
dc.subject.keywordSleep-
dc.subject.localChloride influx-
dc.subject.localGABAA receptors-
dc.subject.localGlutamic acid decarboxylase (GAD)-
dc.subject.localMagnolia obovata-
dc.subject.localObovatol-
dc.subject.localPentobarbital-
dc.subject.localSleep-
dc.description.journalClassY-
Appears in Collections:
Division of Biomedical Research > Genome Editing Research Center > 1. Journal Articles
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