Acute toxicity and pharmacokinetics of 13 nm-sized PEG-coated gold nanoparticles

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dc.contributor.authorW S Cho-
dc.contributor.authorM Cho-
dc.contributor.authorJin Young Jeong-
dc.contributor.authorM Choi-
dc.contributor.authorH Y Cho-
dc.contributor.authorB S Han-
dc.contributor.authorS H Kim-
dc.contributor.authorH O Kim-
dc.contributor.authorYong Taik Lim-
dc.contributor.authorBong Hyun Chung-
dc.contributor.authorJ Jeong-
dc.date.accessioned2017-04-19T09:13:28Z-
dc.date.available2017-04-19T09:13:28Z-
dc.date.issued2009-
dc.identifier.issn0041-008X-
dc.identifier.uri10.1016/j.taap.2008.12.023ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/8885-
dc.description.abstractIn general, gold nanoparticles are recognized as being as nontoxic. Still, there have been some reports on their toxicity, which has been shown to depend on the physical dimension, surface chemistry, and shape of the nanoparticles. In this study, we carry out an in vivo toxicity study using 13 nm-sized gold nanoparticles coated with PEG (MW 5000). In our findings the 13 nm sized PEG-coated gold nanoparticles were seen to induce acute inflammation and apoptosis in the liver. These nanoparticles were found to accumulate in the liver and spleen for up to 7 days after injection and to have long blood circulation times. In addition, transmission electron microscopy showed that numerous cytoplasmic vesicles and lysosomes of liver Kupffer cells and spleen macrophages contained the PEG-coated gold nanoparticles. These findings of toxicity and kinetics of PEG-coated gold nanoparticles may have important clinical implications regarding the safety issue as PEG-coated gold nanoparticles are widely used in biomedical applications.-
dc.publisherElsevier-
dc.titleAcute toxicity and pharmacokinetics of 13 nm-sized PEG-coated gold nanoparticles-
dc.title.alternativeAcute toxicity and pharmacokinetics of 13 nm-sized PEG-coated gold nanoparticles-
dc.typeArticle-
dc.citation.titleToxicology and Applied Pharmacology-
dc.citation.number1-
dc.citation.endPage24-
dc.citation.startPage16-
dc.citation.volume236-
dc.contributor.affiliatedAuthorJin Young Jeong-
dc.contributor.affiliatedAuthorYong Taik Lim-
dc.contributor.affiliatedAuthorBong Hyun Chung-
dc.contributor.alternativeName조완섭-
dc.contributor.alternativeName조민정-
dc.contributor.alternativeName정진영-
dc.contributor.alternativeName최미나-
dc.contributor.alternativeName조혜영-
dc.contributor.alternativeName한범석-
dc.contributor.alternativeName김신희-
dc.contributor.alternativeName김형욱-
dc.contributor.alternativeName임용택-
dc.contributor.alternativeName정봉현-
dc.contributor.alternativeName정자영-
dc.identifier.bibliographicCitationToxicology and Applied Pharmacology, vol. 236, no. 1, pp. 16-24-
dc.identifier.doi10.1016/j.taap.2008.12.023-
dc.subject.keywordaccumulation-
dc.subject.keywordgold nanoparticles-
dc.subject.keywordinflammation-
dc.subject.keywordintravenous injection-
dc.subject.keywordpharmacokinetics-
dc.subject.localaccumulation-
dc.subject.localgold nanoparticles-
dc.subject.localInflammation-
dc.subject.localinflammation-
dc.subject.localnflammation-
dc.subject.localIntravenous injection-
dc.subject.localintravenous injection-
dc.subject.localPharmacokinetics-
dc.subject.localpharmacokinetics-
dc.description.journalClassY-
Appears in Collections:
Division of Research on National Challenges > Environmental diseases research center > 1. Journal Articles
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