Cited 24 time in
- Silymarin inhibits melanin synthesis in melanocyte cells
- Soo-Jin Choo; In Ja Ryoo; Young Hee Kim; G H Xu; Won Gon Kim; K H Kim; S J Moon; E D Son; K Bae; Ick Dong Yoo
- Bibliographic Citation
- Journal of Pharmacy and Pharmacology, vol. 61, no. 5, pp. 663-667
- Publication Year
- Objectives The aim was to search for inhibitors of melanogenesis from natural
Methods The inhibitory effect of silymarin on melanogenesis in a spontaneously
immortalized mouse melanocyte cell line, Mel-Ab, was studied.
Key findings Silymarin significantly prevented melanin production in a dose-dependent
manner with an IC50 value (concentration producing 50%maximal inhibition) of 28.2 mg/ml,
without effects on cell viability. Also, silymarin inhibited L-DOPA oxidation activity of
tyrosinase, the rate-limiting melanogenic enzyme, in cell based-systems but it did not directly
affect cell-free tyrosinase activity. Furthermore,Western blot analysis indicated that silymarin
decreased the expression of tyrosinase protein.
Conclusions This study suggests that the depigmenting effect of silymarin might be
attributable to inhibition of tyrosinase expression and that silymarin may be useful as a
natural skin-lightening agent.
- melanogenesissilymarinskin-lighteningtyrosinase activity
- Appears in Collections:
- Ochang Branch Institute > Chemical Biology Research Center > 1. Journal Articles
Division of Research on National Challenges > Infectious Disease Research Center > 1. Journal Articles
- Files in This Item:
Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.