Silymarin inhibits melanin synthesis in melanocyte cells

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Title
Silymarin inhibits melanin synthesis in melanocyte cells
Author(s)
Soo-Jin Choo; In Ja Ryoo; Young Hee Kim; G H Xu; Won Gon Kim; K H Kim; S J Moon; E D Son; K Bae; Ick Dong Yoo
Bibliographic Citation
Journal of Pharmacy and Pharmacology, vol. 61, no. 5, pp. 663-667
Publication Year
2009
Abstract
Objectives The aim was to search for inhibitors of melanogenesis from natural resources. Methods The inhibitory effect of silymarin on melanogenesis in a spontaneously immortalized mouse melanocyte cell line, Mel-Ab, was studied. Key findings Silymarin significantly prevented melanin production in a dose-dependent manner with an IC50 value (concentration producing 50%maximal inhibition) of 28.2 mg/ml, without effects on cell viability. Also, silymarin inhibited L-DOPA oxidation activity of tyrosinase, the rate-limiting melanogenic enzyme, in cell based-systems but it did not directly affect cell-free tyrosinase activity. Furthermore,Western blot analysis indicated that silymarin decreased the expression of tyrosinase protein. Conclusions This study suggests that the depigmenting effect of silymarin might be attributable to inhibition of tyrosinase expression and that silymarin may be useful as a natural skin-lightening agent.
Keyword
melanogenesissilymarinskin-lighteningtyrosinase activity
ISSN
0022-3573
Publisher
Wiley
DOI
http://dx.doi.org/10.1211/jpp.61.05.0016
Type
Article
Appears in Collections:
Ochang Branch Institute > Chemical Biology Research Center > 1. Journal Articles
Division of Research on National Challenges > Infectious Disease Research Center > 1. Journal Articles
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