Anti-inflammatory and anti-asthmatic effects of resveratrol, a polyphenolic stilbene, in a mouse model of allergic asthma

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dc.contributor.authorMee Young Lee-
dc.contributor.authorS Kim-
dc.contributor.authorOk-Kyoung Kwon-
dc.contributor.authorSei Ryang Oh-
dc.contributor.authorHyeong Kyu Lee-
dc.contributor.authorKyung Seop Ahn-
dc.date.accessioned2017-04-19T09:13:32Z-
dc.date.available2017-04-19T09:13:32Z-
dc.date.issued2009-
dc.identifier.issn1567-5769-
dc.identifier.uri10.1016/j.intimp.2009.01.005ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/8895-
dc.description.abstractAsthma is an inflammatory disease of the airways, and the current focus in managing asthma is the control of inflammation. Resveratrol (3,4,5-trihydroxystilbene) is a polyphenolic stilbene found in the skins of red fruits, including grapes, that may be responsible for some of the health benefits ascribed to consumption of red wine. We investigated the suppressive effects of resveratrol on asthmatic parameters such as cytokine release, eosinophilia, airway hyperresponsiveness, and mucus hypersecretion, in an OVA-induced allergic mouse model of asthma. Resveratrol significantly inhibited increases in T-helper-2-type cytokines such as IL-4 and IL-5 in plasma and bronchoalveolar lavage fluid (BALF), and also effectively suppressed airway hyperresponsiveness, eosinophilia, and mucus hypersecretion, in the asthmatic mouse model. The efficacy of resveratrol was similar to that of dexamethasone, a glucocorticoid used as a positive control. These results suggest that resveratrol may have applications in the treatment of bronchial asthma.-
dc.publisherElsevier-
dc.titleAnti-inflammatory and anti-asthmatic effects of resveratrol, a polyphenolic stilbene, in a mouse model of allergic asthma-
dc.title.alternativeAnti-inflammatory and anti-asthmatic effects of resveratrol, a polyphenolic stilbene, in a mouse model of allergic asthma-
dc.typeArticle-
dc.citation.titleInternational Immunopharmacology-
dc.citation.number4-
dc.citation.endPage424-
dc.citation.startPage418-
dc.citation.volume9-
dc.contributor.affiliatedAuthorMee Young Lee-
dc.contributor.affiliatedAuthorOk-Kyoung Kwon-
dc.contributor.affiliatedAuthorSei Ryang Oh-
dc.contributor.affiliatedAuthorHyeong Kyu Lee-
dc.contributor.affiliatedAuthorKyung Seop Ahn-
dc.contributor.alternativeName이미영-
dc.contributor.alternativeName김소영-
dc.contributor.alternativeName권옥경-
dc.contributor.alternativeName오세량-
dc.contributor.alternativeName이형규-
dc.contributor.alternativeName안경섭-
dc.identifier.bibliographicCitationInternational Immunopharmacology, vol. 9, no. 4, pp. 418-424-
dc.identifier.doi10.1016/j.intimp.2009.01.005-
dc.subject.keywordAirway hyperresponsiveness-
dc.subject.keywordAsthma-
dc.subject.keywordCytokine-
dc.subject.keywordEosinophilia-
dc.subject.keywordResveratrol-
dc.subject.localairway hyperresponsiveness-
dc.subject.localAirway hyper-responsiveness-
dc.subject.localAirway hyperresponsiveness-
dc.subject.localasthma-
dc.subject.localAsthma-
dc.subject.localcytokine-
dc.subject.localCytokines-
dc.subject.localCytokine-
dc.subject.localeosinophilia-
dc.subject.localEosinophilia-
dc.subject.localResveratrol-
dc.subject.localresveratrol-
dc.description.journalClassY-
Appears in Collections:
Ochang Branch Institute > Division of National Bio-Infrastructure > Bio-Resource Central Bank > 1. Journal Articles
Ochang Branch Institute > 1. Journal Articles
Ochang Branch Institute > Natural Product Research Center > 1. Journal Articles
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