DC Field | Value | Language |
---|---|---|
dc.contributor.author | Mee Young Lee | - |
dc.contributor.author | S Kim | - |
dc.contributor.author | Ok-Kyoung Kwon | - |
dc.contributor.author | Sei Ryang Oh | - |
dc.contributor.author | Hyeong Kyu Lee | - |
dc.contributor.author | Kyung Seop Ahn | - |
dc.date.accessioned | 2017-04-19T09:13:32Z | - |
dc.date.available | 2017-04-19T09:13:32Z | - |
dc.date.issued | 2009 | - |
dc.identifier.issn | 1567-5769 | - |
dc.identifier.uri | 10.1016/j.intimp.2009.01.005 | ko |
dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/8895 | - |
dc.description.abstract | Asthma is an inflammatory disease of the airways, and the current focus in managing asthma is the control of inflammation. Resveratrol (3,4,5-trihydroxystilbene) is a polyphenolic stilbene found in the skins of red fruits, including grapes, that may be responsible for some of the health benefits ascribed to consumption of red wine. We investigated the suppressive effects of resveratrol on asthmatic parameters such as cytokine release, eosinophilia, airway hyperresponsiveness, and mucus hypersecretion, in an OVA-induced allergic mouse model of asthma. Resveratrol significantly inhibited increases in T-helper-2-type cytokines such as IL-4 and IL-5 in plasma and bronchoalveolar lavage fluid (BALF), and also effectively suppressed airway hyperresponsiveness, eosinophilia, and mucus hypersecretion, in the asthmatic mouse model. The efficacy of resveratrol was similar to that of dexamethasone, a glucocorticoid used as a positive control. These results suggest that resveratrol may have applications in the treatment of bronchial asthma. | - |
dc.publisher | Elsevier | - |
dc.title | Anti-inflammatory and anti-asthmatic effects of resveratrol, a polyphenolic stilbene, in a mouse model of allergic asthma | - |
dc.title.alternative | Anti-inflammatory and anti-asthmatic effects of resveratrol, a polyphenolic stilbene, in a mouse model of allergic asthma | - |
dc.type | Article | - |
dc.citation.title | International Immunopharmacology | - |
dc.citation.number | 4 | - |
dc.citation.endPage | 424 | - |
dc.citation.startPage | 418 | - |
dc.citation.volume | 9 | - |
dc.contributor.affiliatedAuthor | Mee Young Lee | - |
dc.contributor.affiliatedAuthor | Ok-Kyoung Kwon | - |
dc.contributor.affiliatedAuthor | Sei Ryang Oh | - |
dc.contributor.affiliatedAuthor | Hyeong Kyu Lee | - |
dc.contributor.affiliatedAuthor | Kyung Seop Ahn | - |
dc.contributor.alternativeName | 이미영 | - |
dc.contributor.alternativeName | 김소영 | - |
dc.contributor.alternativeName | 권옥경 | - |
dc.contributor.alternativeName | 오세량 | - |
dc.contributor.alternativeName | 이형규 | - |
dc.contributor.alternativeName | 안경섭 | - |
dc.identifier.bibliographicCitation | International Immunopharmacology, vol. 9, no. 4, pp. 418-424 | - |
dc.identifier.doi | 10.1016/j.intimp.2009.01.005 | - |
dc.subject.keyword | Airway hyperresponsiveness | - |
dc.subject.keyword | Asthma | - |
dc.subject.keyword | Cytokine | - |
dc.subject.keyword | Eosinophilia | - |
dc.subject.keyword | Resveratrol | - |
dc.subject.local | airway hyperresponsiveness | - |
dc.subject.local | Airway hyper-responsiveness | - |
dc.subject.local | Airway hyperresponsiveness | - |
dc.subject.local | asthma | - |
dc.subject.local | Asthma | - |
dc.subject.local | cytokine | - |
dc.subject.local | Cytokines | - |
dc.subject.local | Cytokine | - |
dc.subject.local | eosinophilia | - |
dc.subject.local | Eosinophilia | - |
dc.subject.local | Resveratrol | - |
dc.subject.local | resveratrol | - |
dc.description.journalClass | Y | - |
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