Tyrosinase inhibitory polyphenols from roots of Morus ihou = 뽕나무뿌리로부터 타이로신 저해제인 폴리페놀 화합물의 개발

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dc.contributor.authorS H Jeong-
dc.contributor.authorYoung Bae Ryu-
dc.contributor.authorM J Curtis-Long-
dc.contributor.authorHyung Won Ryu-
dc.contributor.authorY S Baek-
dc.contributor.authorJ E Kang-
dc.contributor.authorWoo Song Lee-
dc.contributor.authorK H Park-
dc.date.accessioned2017-04-19T09:13:32Z-
dc.date.available2017-04-19T09:13:32Z-
dc.date.issued2009-
dc.identifier.issn00218561-
dc.identifier.uri10.1021/jf8033286ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/8897-
dc.description.abstractTwelve polyphenols (1-12) possessing tyrosinase inhibitory properties were isolated from the methanol (95%) extract of Morus Ihou. The isolated compounds consisted of four flavanones (1 -4), four flavones (5-8), and four phenylbenzofuranes (9-12). Moracin derivative 12 proved to be new a compound which was fully characterized. Compounds 1-12 were evaluated for both monophenolase and diphenolase (the two steps catalyzed by tyrosinase) inhibition to identify the structural characteristics required for mushroom tyrosinase inhibition. We observed that all parent compounds (1, 5, and 9) possessing an unsubstituted resorcinol group were highly effective inhibitors of monophenolase activity (IC50 values of 1.3, 1.2, and 7.4 μM). The potency of the inhibitors diminished with alkyl substitution on either the aromatic ring or the hydroxyl functions. Interestingly, flavone 5 was shown to possess only monophenolase inhibitory activity, but flavanone 1 and phenylbenzofuran 9 inhibited diphenolase as well as monophenolase significantly. The inhibitory mode of these species was also dependent upon the skeleton: phenylbenzofuran 9 manifested a simple competitive inhibition mode for monophenolase and diphenolase; on the other hand flavanone 1 (monophenolase, K3 = 0.1966 min-1 μM-1 k4= 0.0082 min ∼1, and Kiapp = 0.0468 μM; diphenolase, k3 = 0.0014 min-1 μM-1 k4 = 0.0013 min-1, and Kiapp = 0.8996 μM) and flavone 5 both showed time-dependent inhibition against monophenolase. Compound 1 operated according to the simple reversible slow binding model whereas compound 5 operated under the enzyme isomerization model.-
dc.publisherAmer Chem Soc-
dc.titleTyrosinase inhibitory polyphenols from roots of Morus ihou = 뽕나무뿌리로부터 타이로신 저해제인 폴리페놀 화합물의 개발-
dc.title.alternativeTyrosinase inhibitory polyphenols from roots of Morus ihou-
dc.typeArticle-
dc.citation.titleJournal of Agricultural and Food Chemistry-
dc.citation.number4-
dc.citation.endPage1203-
dc.citation.startPage1195-
dc.citation.volume57-
dc.contributor.affiliatedAuthorYoung Bae Ryu-
dc.contributor.affiliatedAuthorHyung Won Ryu-
dc.contributor.affiliatedAuthorWoo Song Lee-
dc.contributor.alternativeName정성훈-
dc.contributor.alternativeName류영배-
dc.contributor.alternativeNameCurtis-Long-
dc.contributor.alternativeName류형원-
dc.contributor.alternativeName백윤수-
dc.contributor.alternativeName강재은-
dc.contributor.alternativeName이우송-
dc.contributor.alternativeName박기훈-
dc.identifier.bibliographicCitationJournal of Agricultural and Food Chemistry, vol. 57, no. 4, pp. 1195-1203-
dc.identifier.doi10.1021/jf8033286-
dc.subject.keywordflavonoid-
dc.subject.keywordmorus Ihou-
dc.subject.keywordphenylbenzofuran-
dc.subject.keywordslow-binding-
dc.subject.keywordtyrosinase-
dc.subject.localflavonoid-
dc.subject.localFlavonoid-
dc.subject.localmorus Ihou-
dc.subject.localMorus lhou-
dc.subject.localphenylbenzofuran-
dc.subject.localslow-binding-
dc.subject.localtyrosinase-
dc.subject.localTyrosinase-
dc.description.journalClassY-
Appears in Collections:
Jeonbuk Branch Institute > Functional Biomaterial Research Center > 1. Journal Articles
Ochang Branch Institute > Natural Medicine Research Center > 1. Journal Articles
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