Rengyolone inhibits apoptosis via etoposide-induced caspase downregulation

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dc.contributor.authorJin Hee Kim-
dc.contributor.authorC H Lee-
dc.date.accessioned2017-04-19T09:13:32Z-
dc.date.available2017-04-19T09:13:32Z-
dc.date.issued2009-
dc.identifier.issn1017-7825-
dc.identifier.uri10.4014/jmb.0804.253ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/8900-
dc.description.abstractIn the course of screening for substances inhibiting apoptosis of U937 human leukemia cells induced by etoposide (10 μg/ml), Forsythiae fructus, which showed a high level of inhibition, was selected. The regulating compounds were purified from the ethyl acetate extract by silica gel column chromatography and HPLC. The active substance was purified and identified as rengyolone by spectroscopic methods. This compound showed inhibitory activity on caspase-3 induction, a major protease of the apoptosis cascade, with an IC50 value of 38.96 μM after 8 h of etoposide treatment in U937 cells. The expression level of caspase-3 and poly(ADP-ribose) polymerase (PARP) were dose-dependently inhibited by the compound, suggesting that rengyolone inhibits etoposide-induced apoptosis via downregulation of caspases.-
dc.publisherKorea Soc-Assoc-Inst-
dc.titleRengyolone inhibits apoptosis via etoposide-induced caspase downregulation-
dc.title.alternativeRengyolone inhibits apoptosis via etoposide-induced caspase downregulation-
dc.typeArticle-
dc.citation.titleJournal of Microbiology and Biotechnology-
dc.citation.number3-
dc.citation.endPage290-
dc.citation.startPage286-
dc.citation.volume19-
dc.contributor.affiliatedAuthorJin Hee Kim-
dc.contributor.alternativeName김진희-
dc.contributor.alternativeName이충환-
dc.identifier.bibliographicCitationJournal of Microbiology and Biotechnology, vol. 19, no. 3, pp. 286-290-
dc.identifier.doi10.4014/jmb.0804.253-
dc.subject.keywordapoptosis-
dc.subject.keywordrengyolone-
dc.subject.localapoptosis-
dc.subject.localApoptosis-
dc.subject.localrengyolone-
dc.description.journalClassY-
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