Backbone resonance assignment of a proteolysis-resistant fragment in the oxygen-dependent degradation domain of the hypoxia inducible factor 1alpha

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dc.contributor.authorD H Kim-
dc.contributor.authorSi-Hyung Lee-
dc.contributor.authorSeung-Wook Chi-
dc.contributor.authorKi Hoon Nam-
dc.contributor.authorKyou Hoon Han-
dc.date.accessioned2017-04-19T09:13:37Z-
dc.date.available2017-04-19T09:13:37Z-
dc.date.issued2009-
dc.identifier.issn1016-8478-
dc.identifier.uri10.1007/s10059-009-0065-4ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/8908-
dc.description.abstractHypoxia-inducible factor 1α (HIF1α) is a transcription factor that plays a key role in the adaptation of cells to low oxygen stress and oxygen homeostasis. The oxygen-dependent degradation (ODD) domain of HIF1α responsible for the negative regulation of HIF1α in normoxia is intrinsically unfolded. Here, we carried out the backbone 1H, 15N, and 13C resonance assignment of a proteolysis-resistant fragment (residues 404-477) in the HIF1α ODD domain using NMR spectroscopy. About 98% (344/352) of all the 1HN, 15N, 13Cα, 13Cβ, and 13CO resonances were unambiguously assigned. The results will be useful for further investigation of the structural and dynamic states of the HIF1α ODD domain and its interaction with binding partners.-
dc.publisherKorea Soc-Assoc-Inst-
dc.titleBackbone resonance assignment of a proteolysis-resistant fragment in the oxygen-dependent degradation domain of the hypoxia inducible factor 1alpha-
dc.title.alternativeBackbone resonance assignment of a proteolysis-resistant fragment in the oxygen-dependent degradation domain of the hypoxia inducible factor 1alpha-
dc.typeArticle-
dc.citation.titleMolecules and Cells-
dc.citation.number4-
dc.citation.endPage496-
dc.citation.startPage493-
dc.citation.volume27-
dc.contributor.affiliatedAuthorSi-Hyung Lee-
dc.contributor.affiliatedAuthorSeung-Wook Chi-
dc.contributor.affiliatedAuthorKi Hoon Nam-
dc.contributor.affiliatedAuthorKyou Hoon Han-
dc.contributor.alternativeName김도형-
dc.contributor.alternativeName이시형-
dc.contributor.alternativeName지승욱-
dc.contributor.alternativeName남기훈-
dc.contributor.alternativeName한규훈-
dc.identifier.bibliographicCitationMolecules and Cells, vol. 27, no. 4, pp. 493-496-
dc.identifier.doi10.1007/s10059-009-0065-4-
dc.subject.keywordhypoxia-inducible factor 1α-
dc.subject.keywordNMR spectroscopy-
dc.subject.keywordoxygen-dependent degradation domain-
dc.subject.keywordresonance assignment-
dc.subject.localhypoxia-inducible factor 1α-
dc.subject.localHypoxia-inducible factor-1α-
dc.subject.localhypoxia inducible factor-1α (HIF-1α)-
dc.subject.localhypoxia-inducible factor-1α-
dc.subject.localHypoxia inducible factor-1α-
dc.subject.localHypoxic inducible factor-1a-
dc.subject.localHypoxia-inducible factor 1 alpha-
dc.subject.localNMR spectroscopy-
dc.subject.localoxygen-dependent degradation domain-
dc.subject.localresonance assignment-
dc.description.journalClassY-
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Division of Biomedical Research > 1. Journal Articles
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