Inhibition of phenotypic and functional maturation of dendritic cells by manassantin A

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dc.contributor.authorJ Y Kim-
dc.contributor.authorJong Soon Kang-
dc.contributor.authorHwan Mook Kim-
dc.contributor.authorYoung Kook Kim-
dc.contributor.authorH K Lee-
dc.contributor.authorS Song-
dc.contributor.authorJ T Hong-
dc.contributor.authorY Kim-
dc.contributor.authorS B Han-
dc.date.accessioned2017-04-19T09:13:45Z-
dc.date.available2017-04-19T09:13:45Z-
dc.date.issued2009-
dc.identifier.issn13478613-
dc.identifier.uri10.1254/jphs.08299FPko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/8948-
dc.description.abstractManassantin A (MSA) inhibits nitric oxide production by macrophages through the inhibition of NF-κB activation, but the effect of MSA on dendritic cells has not been elucidated yet. Here we investigated the inhibitory effects of MSA on immune functions of dendritic cells (DCs). MSA inhibited lipopolysaccharide (LPS)-induced phenotypic maturation of DCs, which was proved by the decreased expression of CD40, CD80, CD86, MHC-I, and MHC-II. MSA also inhibited functional maturation of DCs, that is, decreased the gene expression of IL-12, IL-1β, TNF-α, and IFN-α/β; enhanced antigen capture capacity of DCs; and impaired induction of allogenic T cell activation. As a mechanism of action, MSA inhibited LPS-induced activation of NF-κB, ERK, p38, and JNK, which played pivotal roles in toll-like receptor 4-mediated DC maturation. Collectively, these results suggested that MSA might be used for the treatment of DC-related immune diseases.-
dc.publisherJapanese Pharmacological Soc-
dc.titleInhibition of phenotypic and functional maturation of dendritic cells by manassantin A-
dc.title.alternativeInhibition of phenotypic and functional maturation of dendritic cells by manassantin A-
dc.typeArticle-
dc.citation.titleJournal of Pharmacological Sciences-
dc.citation.number4-
dc.citation.endPage592-
dc.citation.startPage583-
dc.citation.volume109-
dc.contributor.affiliatedAuthorJong Soon Kang-
dc.contributor.alternativeName김지연-
dc.contributor.alternativeName강종순-
dc.contributor.alternativeName김환묵-
dc.contributor.alternativeName김영국-
dc.contributor.alternativeName이홍경-
dc.contributor.alternativeName송석길-
dc.contributor.alternativeName홍진태-
dc.contributor.alternativeName김영수-
dc.contributor.alternativeName한상배-
dc.identifier.bibliographicCitationJournal of Pharmacological Sciences, vol. 109, no. 4, pp. 583-592-
dc.identifier.doi10.1254/jphs.08299FP-
dc.subject.keywordmanassantin A-
dc.subject.keyworddendritic cell-
dc.subject.keywordmaturation-
dc.subject.keywordmitogen-activated protein kinase-
dc.subject.keywordNF-κB-
dc.subject.localmanassantin A-
dc.subject.localdendritic cell-
dc.subject.localDendritic cell-
dc.subject.localmaturation-
dc.subject.localMaturation-
dc.subject.localmitogen-activated protein kinase-
dc.subject.localMitogen activated protein kinase-
dc.subject.localNF-κB-
dc.subject.localNF-kB-
dc.description.journalClassY-
Appears in Collections:
Ochang Branch Institute > Division of Bioinfrastructure > Laboratory Animal Resource Center > 1. Journal Articles
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