The association of COMT gene polymorphism and tourette syndrome : a family based and case control study = 한국인 뚜렛장애에서 환자군과 가족군간의 COMT 유전자 다형성의 연관성

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dc.contributor.authorW S Lim-
dc.contributor.authorM H Lim-
dc.contributor.authorEun Young Song-
dc.contributor.authorM Y Park-
dc.contributor.authorJ W Kim-
dc.contributor.authorT H Kim-
dc.contributor.authorS H Shim-
dc.contributor.authorT W Park-
dc.contributor.authorH W Kim-
dc.date.accessioned2017-04-19T09:13:46Z-
dc.date.available2017-04-19T09:13:46Z-
dc.date.issued2009-
dc.identifier.issn1225-729X-
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/8956-
dc.description.abstractObjectives : Tourette disorder is known to be a disease with a strong genetic trait. There has been some recent research on the relationship between the allelic frequency distribution and Tourette disorder. In Korea, the relationship between the genetic type and the alleles for the COMT gene has been studied in Tourette patients. Methods : Seventy two patients who were diagnosed with Tourette disorder according to the DSM-IV diagnostic criteria were selected for this study. The diagnosis and clinical features were confirmed by the Yale Global Tic Severity Scale. For the control group, the parents of the patients were chosen. Blood samples were taken from the 289 subjects. DNA was extracted from the blood lymphocytes and PCR was performed for assessing COMT gene. Results : On comparing the Tourette disorder transmitted group and the not-transmitted group, no significant difference was seen between the COMT genetic type and the allelic distribution. Conclusion : Even though this result is viewed that there is no relationship between Tourette disorder and the COMT gene, it is difficult to firmly accept this negative result. Follow up studies with a larger patient population or pure subgroups are expected in the future.-
dc.publisherKorea Soc-Assoc-Inst-
dc.titleThe association of COMT gene polymorphism and tourette syndrome : a family based and case control study = 한국인 뚜렛장애에서 환자군과 가족군간의 COMT 유전자 다형성의 연관성-
dc.title.alternativeThe association of COMT gene polymorphism and tourette syndrome : a family based and case control study-
dc.typeArticle-
dc.citation.titleJournal of Korean Academy of Child and Adolescent Psychiatry-
dc.citation.number1-
dc.citation.endPage9-
dc.citation.startPage3-
dc.citation.volume20-
dc.contributor.affiliatedAuthorEun Young Song-
dc.contributor.alternativeName임원석-
dc.contributor.alternativeName임명호-
dc.contributor.alternativeName송은영-
dc.contributor.alternativeName박미영-
dc.contributor.alternativeName김종완-
dc.contributor.alternativeName김태현-
dc.contributor.alternativeName심세훈-
dc.contributor.alternativeName박태원-
dc.contributor.alternativeName김현우-
dc.identifier.bibliographicCitationJournal of Korean Academy of Child and Adolescent Psychiatry, vol. 20, no. 1, pp. 3-9-
dc.subject.keywordTourette disorder-
dc.subject.keywordCOMT gene-
dc.subject.keywordPolymorphism-
dc.subject.keywordFamily-based study-
dc.subject.keywordCase control study-
dc.subject.localTourette disorder-
dc.subject.localCOMT gene-
dc.subject.localpolymorphism-
dc.subject.localPolymorphism-
dc.subject.localFamily-based study-
dc.subject.localcase-control study-
dc.subject.localCase-control study-
dc.subject.localCase control study-
dc.description.journalClassN-
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