Protein tyrosine phosphatase 1B inhibitory effects of depsidone and pseudodepsidone metabolites from the Antarctic lichen Stereocaulon alpinum
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| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | C Seo | - |
| dc.contributor.author | J H Sohn | - |
| dc.contributor.author | Jong Seog Ahn | - |
| dc.contributor.author | J H Yim | - |
| dc.contributor.author | H K Lee | - |
| dc.contributor.author | H Oh | - |
| dc.date.accessioned | 2017-04-19T09:13:50Z | - |
| dc.date.available | 2017-04-19T09:13:50Z | - |
| dc.date.issued | 2009 | - |
| dc.identifier.issn | 0960-894X | - |
| dc.identifier.uri | 10.1016/j.bmcl.2009.03.108 | ko |
| dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/8965 | - |
| dc.description.abstract | Seven phenolic lichen metabolites (1-7) have been isolated from a methanol extract of the Antarctic lichen Stereocaulon alpinum by various chromatographic methods. The structures of these compounds were determined mainly by analysis of NMR spectroscopic data. A depsidone-type compound, lobaric acid (1) and two pseudodepsidone-type compounds, 2 and 3, exhibited potent inhibitory activity against protein tyrosine phosphatase 1B (PTP1B) with IC50 values of 0.87 μM, 6.86 μM, and 2.48 μM, respectively. Kinetic analyses of PTP1B inhibition by compounds 1 and 2 suggested that these compounds inhibited PTP1B activity in a non-competitive manner. | - |
| dc.publisher | Elsevier | - |
| dc.title | Protein tyrosine phosphatase 1B inhibitory effects of depsidone and pseudodepsidone metabolites from the Antarctic lichen Stereocaulon alpinum | - |
| dc.title.alternative | Protein tyrosine phosphatase 1B inhibitory effects of depsidone and pseudodepsidone metabolites from the Antarctic lichen Stereocaulon alpinum | - |
| dc.type | Article | - |
| dc.citation.title | Bioorganic & Medicinal Chemistry Letters | - |
| dc.citation.number | 10 | - |
| dc.citation.endPage | 2803 | - |
| dc.citation.startPage | 2801 | - |
| dc.citation.volume | 19 | - |
| dc.contributor.affiliatedAuthor | Jong Seog Ahn | - |
| dc.contributor.alternativeName | 서찬곤 | - |
| dc.contributor.alternativeName | 손재학 | - |
| dc.contributor.alternativeName | 안종석 | - |
| dc.contributor.alternativeName | 임정한 | - |
| dc.contributor.alternativeName | 이홍금 | - |
| dc.contributor.alternativeName | 오현철 | - |
| dc.identifier.bibliographicCitation | Bioorganic & Medicinal Chemistry Letters, vol. 19, no. 10, pp. 2801-2803 | - |
| dc.identifier.doi | 10.1016/j.bmcl.2009.03.108 | - |
| dc.subject.keyword | depsidones | - |
| dc.subject.keyword | lichen metabolites | - |
| dc.subject.keyword | non-competitive inhibitors | - |
| dc.subject.keyword | protein tyrosine phosphatase 1B (PTP1B) | - |
| dc.subject.keyword | stereocaulon alpinum | - |
| dc.subject.local | depsidones | - |
| dc.subject.local | Lichen metabolites | - |
| dc.subject.local | lichen metabolites | - |
| dc.subject.local | Non-competitive inhibitor | - |
| dc.subject.local | non-competitive inhibitors | - |
| dc.subject.local | Non-competitive inhibitors | - |
| dc.subject.local | non-competitive inhibitor | - |
| dc.subject.local | protein tyrosine phosphatase 1B | - |
| dc.subject.local | protein tyrosine phosphatase-1B (PTP1B) | - |
| dc.subject.local | Protein tyrosine phosphatase 1B | - |
| dc.subject.local | protein tyrosine phosphatase 1B (PTP1B) | - |
| dc.subject.local | protein tyrosine phosphatase 1B (FTPIB) | - |
| dc.subject.local | Protein tyrosine phosphatase 1B (PTP1B) | - |
| dc.subject.local | stereocaulon alpinum | - |
| dc.description.journalClass | Y | - |
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