Inhibitory effects of quercetin 3-rhamnoside on influenza A virus replication

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dc.contributor.authorH J Choi-
dc.contributor.authorJ H Song-
dc.contributor.authorK S Park-
dc.contributor.authorDur Han Kwon-
dc.date.accessioned2017-04-19T09:13:50Z-
dc.date.available2017-04-19T09:13:50Z-
dc.date.issued2009-
dc.identifier.issn0928-0987-
dc.identifier.uri10.1016/j.ejps.2009.03.002ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/8968-
dc.description.abstractInfluenza viruses cause significant morbidity and mortality in humans through epidemics or pandemics. The lack of effective therapeutical treatment underlines the importance of research for new antiviral compounds. Flavonoids widely exist in the plant kingdom, and their antiviral activities against various viruses have been recently reported. In this study, the anti-influenza A/WS/33 virus of quercetin 3-rhamnoside (Q3R) from Houttuynia cordata was evaluated using a cytopathic effect (CPE) reduction method, the assay results demonstrated that Q3R possessed strong anti-influenza A/WS/33 virus reducing the formation of a visible CPE. Q3R also did inhibit virus replication in the initial stage of virus infection by indirect interaction with virus particles. However, oseltamivir has relative weaker efficacy compared to Q3R. Therefore, these findings provide important information for the utilization of Q3R for influenza treatment.-
dc.publisherElsevier-
dc.titleInhibitory effects of quercetin 3-rhamnoside on influenza A virus replication-
dc.title.alternativeInhibitory effects of quercetin 3-rhamnoside on influenza A virus replication-
dc.typeArticle-
dc.citation.titleEuropean Journal of Pharmaceutical Sciences-
dc.citation.number3-
dc.citation.endPage333-
dc.citation.startPage329-
dc.citation.volume37-
dc.contributor.affiliatedAuthorDur Han Kwon-
dc.contributor.alternativeName최화정-
dc.contributor.alternativeName송재형-
dc.contributor.alternativeName박귀성-
dc.contributor.alternativeName권두한-
dc.identifier.bibliographicCitationEuropean Journal of Pharmaceutical Sciences, vol. 37, no. 3, pp. 329-333-
dc.identifier.doi10.1016/j.ejps.2009.03.002-
dc.subject.keywordantiviral activity-
dc.subject.keywordhouttuynia cordata-
dc.subject.keywordinfluenza-
dc.subject.keywordquercetin 3-rhamnoside (Q3R)-
dc.subject.localAntiviral activity-
dc.subject.localantiviral activity-
dc.subject.localHouttuynia cordata-
dc.subject.localhouttuynia cordata-
dc.subject.localinfluenza-
dc.subject.localInfluenza-
dc.subject.localQuercetin 3-rhamnoside-
dc.subject.localquercetin 3-rhamnoside (Q3R)-
dc.description.journalClassY-
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