Isolation of betulinic acid, its methyl ester and guaiane sesquiterpenoids with protein tyrosine phosphatase 1B inhibitory activity from the roots of Saussurea lappa C.B.Clarke

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Title
Isolation of betulinic acid, its methyl ester and guaiane sesquiterpenoids with protein tyrosine phosphatase 1B inhibitory activity from the roots of Saussurea lappa C.B.Clarke
Author(s)
J Y Choi; M Na; I H Hwang; S H Lee; Eun Young Bae; Bo Yeon KimJong Seog Ahn
Bibliographic Citation
Molecules, vol. 14, no. 1, pp. 266-272
Publication Year
2009
Abstract
Activity-guided fractionation of a MeOH extract of the roots of Saussurea lappa C.B.Clarke (Compositae), using an in vitro protein tyrosine phosphatase 1B (PTP1B) inhibition assay, led to the isolation of four active constituents: betulinic acid (1), betulinic acid methyl ester (2), mokko lactone (3) and dehydrocostuslactone (4), along with nine inactive compounds. Our findings indicate that betulinic acid (1) and its methyl ester 2, as well as the two guaiane sesquiterpenoids 3 and 4 are potential lead moieties for the development of new PTP1B inhibitors.
Keyword
betulinic acidbetulinic acid methyl esterdehydrocostuslactonemokko lactoneprotein tyrosine phosphatase 1Bsaussurea lappa C.B.Clarke
ISSN
1420-3049
Publisher
MDPI
DOI
http://dx.doi.org/10.3390/molecules14010266
Type
Article
Appears in Collections:
Ochang Branch Institute > Chemical Biology Research Center > 1. Journal Articles
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