Prenylisoflavonoids from Erythrina senegalensis as novel HIV-1 protease inhibitors

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Title
Prenylisoflavonoids from Erythrina senegalensis as novel HIV-1 protease inhibitors
Author(s)
J Lee; W K Oh; Jong Seog Ahn; Y H Kim; J T Mbafor; J Wandji; Z T Fomum
Bibliographic Citation
Planta Medica, vol. 75, no. 3, pp. 268-270
Publication Year
2009
Abstract
Eight compounds were isolated from the CH (2)Cl (2) extracts of ERYTHRINA SENEGALENSIS to assess HIV-1 protease (PR) activity inhibition. The prenylated isoflavone structures, identified by spectroscopic analysis, were 8-prenylluteone ( 1), auriculatin ( 2), erysenegalensein O ( 3), erysenegalensein D ( 4), erysenegalensein N ( 5), derrone ( 6), alpinumisoflavone ( 7), and 6,8-diprenylgenistein ( 8). The constituents showed dose-dependent inhibitory activities on HIV-1 PR with IC (50) values from 0.5 to 30.0 muM. Compounds 1 - 5 possessing two hydroxy groups in the 2' and 4' positions of the B ring, potently inhibited HIV-1 PR activity. In addition, 6,8-diprenylgenistein ( 8) with two prenyl groups in the 6 and 8 positions of the A ring and one hydroxy group in the 4' position of B-ring was the most potent HIV-1 PR inhibitor.
Keyword
erythrina senegalensisleguminosaeprenylated isoflavonoidsHIV-1 protease
ISSN
0032-0943
Publisher
Georg Thieme Verlag Kg
DOI
http://dx.doi.org/10.1055/s-0028-1088395
Type
Article
Appears in Collections:
Ochang Branch Institute > Chemical Biology Research Center > 1. Journal Articles
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