Anti-inflammatory activity of (-)-aptosimon isolated from Daphne genkwa in RAW264.7 cells = 압토시몬의 항염효과

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Title
Anti-inflammatory activity of (-)-aptosimon isolated from Daphne genkwa in RAW264.7 cells = 압토시몬의 항염효과
Author(s)
M Y Lee; B Y Park; Ok-Kyoung Kwon; Ji Eun Yuk; Sei Ryang Oh; Hui-Seong Kim; Hyeong Kyu Lee; Kyung Seop Ahn
Bibliographic Citation
International Immunopharmacology, vol. 9, no. 7, pp. 878-885
Publication Year
2009
Abstract
In the present study, we investigated that (-)-aptosimon, isolated from flower buds of Daphne genkwa, inhibited cyclooxygenase-2 (COX-2) and inducible nitric oxide (NO) synthase (iNOS) expression in lipopolysaccharide (LPS)-stimulated RAW264.7 cells. Similarly, (-)-aptosimon suppressed tumor necrosis factor (TNF)-α production. Our results clearly indicated that (-)-aptosimon inhibited LPS-induced nuclear factor-κB (NF-κB) activation, by preventing degradation of the inhibitor kappa B-alpha (IκB-α). (-)-Aptosimon also inhibited interleukin-4 (IL-4) and interleukin-13 (IL-13) production in ConA-induced splenocytes. In conclusion, the anti-inflammatory effects of (-)-aptosimon are attributed to the suppression of pro-inflammatory cytokines and mediators by blocking NF-κB activation. These data suggest that (-)-aptosimon as a potential therapeutic agent for inflammation-associated disorders.
Keyword
(-)-aptosimonanti-inflammatoryCOX-2IL-13IL-4iNOS
ISSN
1567-5769
Publisher
Elsevier
DOI
http://dx.doi.org/10.1016/j.intimp.2009.03.012
Type
Article
Appears in Collections:
Ochang Branch Institute > Division of National Bio-Infrastructure > Bio-Resource Central Bank > 1. Journal Articles
Ochang Branch Institute > 1. Journal Articles
Ochang Branch Institute > Natural Product Research Center > 1. Journal Articles
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