2-substitiuted thio- and amino-5,8-dimethoxy-1,4-naphthoquinones as a novel class of Acyl-CoA: cholestrol acyltransferase inhibitors

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dc.contributor.authorG N Shen-
dc.contributor.authorJung Ho Choi-
dc.contributor.authorK Gajulapati-
dc.contributor.authorJ H Lee-
dc.contributor.authorYoung Kook Kim-
dc.contributor.authorMun Chual Rho-
dc.contributor.authorS H Jung-
dc.contributor.authorKyeong Lee-
dc.contributor.authorS S Han-
dc.contributor.authorG Y Song-
dc.contributor.authorY Choi-
dc.date.accessioned2017-04-19T09:14:00Z-
dc.date.available2017-04-19T09:14:00Z-
dc.date.issued2009-
dc.identifier.issn0253-2964-
dc.identifier.uri10.5012/bkcs.2009.30.5.1088ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/8994-
dc.description.abstractA series of 2-alkyl or 2-arylthio-5,8-dimethoxy-1,4-naphthoquinones (2-Thio-DMNQ, 5a-s) and 2-alkylamino-5,8-dimethoxy-1,4-naphthoquinones (2-Amino-DMNQ, 6a-k) was synthesized and evaluated for their ACAT inhibitory activities. Among them, the 2-dodecylthio-DMNQ 5l and 2-isobutylamidoundodecylthio-DMNQ 5r showed the most potent ACAT inhibitory activities with IC50 value of 22.8 and 24.4 μM, respectively. In a structure-activity relationship study, 2-thio-DMNQs with side chains of carbon number 11 ~ 15 exhibited significant ACAT inhibitory activities.-
dc.publisherWiley-
dc.title2-substitiuted thio- and amino-5,8-dimethoxy-1,4-naphthoquinones as a novel class of Acyl-CoA: cholestrol acyltransferase inhibitors-
dc.title.alternative2-substitiuted thio- and amino-5,8-dimethoxy-1,4-naphthoquinones as a novel class of Acyl-CoA: cholestrol acyltransferase inhibitors-
dc.typeArticle-
dc.citation.titleBulletin of Korean Chemical Society-
dc.citation.number5-
dc.citation.endPage1092-
dc.citation.startPage1088-
dc.citation.volume30-
dc.contributor.affiliatedAuthorJung Ho Choi-
dc.contributor.affiliatedAuthorYoung Kook Kim-
dc.contributor.affiliatedAuthorMun Chual Rho-
dc.contributor.affiliatedAuthorKyeong Lee-
dc.contributor.alternativeNameShen-
dc.contributor.alternativeName최정호-
dc.contributor.alternativeNameGajulapati-
dc.contributor.alternativeName이지현-
dc.contributor.alternativeName김영국-
dc.contributor.alternativeName노문철-
dc.contributor.alternativeName정상훈-
dc.contributor.alternativeName이경-
dc.contributor.alternativeName한성식-
dc.contributor.alternativeName송규용-
dc.contributor.alternativeName최용석-
dc.identifier.bibliographicCitationBulletin of Korean Chemical Society, vol. 30, no. 5, pp. 1088-1092-
dc.identifier.doi10.5012/bkcs.2009.30.5.1088-
dc.subject.keywordnaphthoquinones-
dc.subject.keywordmast cells, acyl CoA-
dc.subject.keywordCholestrol Acyl Transferase (ACAT)-
dc.subject.keywordstructure-activity-
dc.subject.localnaphthoquinones-
dc.subject.localmast cells, acyl CoA-
dc.subject.localACAT (acyl-CoA: cholesterol acyltransferase)-
dc.subject.localAcyl-CoA:cholesterol acyltransferase (ACAT)-
dc.subject.localcholesterol acytransferase (ACAT)-
dc.subject.localCholestrol Acyl Transferase (ACAT)-
dc.subject.localAcyl CoA: cholesterol acyltransferase (ACAT)-
dc.subject.localACAT (Acyl-CoA:cholesterol acyltransferase)-
dc.subject.localAcyl-CoA:cholesterol acyltransferase-
dc.subject.localACAT-
dc.subject.localAcyl-CoA: cholesterol acyltransferase-
dc.subject.localacyl-CoA:cholesterol acyltransferase (ACAT)-
dc.subject.localAcyl-CoA: cholesterol acyltransferase (ACAT)-
dc.subject.localAcyl-coenzyme A: cholesterol acyltransferase (ACAT)-
dc.subject.localCholesterol acytransferase (ACAT)-
dc.subject.localcholestrol acyl transferase (ACAT)-
dc.subject.localstructure-activity-
dc.description.journalClassY-
Appears in Collections:
Jeonbuk Branch Institute > Functional Biomaterial Research Center > 1. Journal Articles
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