DC Field | Value | Language |
---|---|---|
dc.contributor.author | G N Shen | - |
dc.contributor.author | Jung Ho Choi | - |
dc.contributor.author | K Gajulapati | - |
dc.contributor.author | J H Lee | - |
dc.contributor.author | Young Kook Kim | - |
dc.contributor.author | Mun Chual Rho | - |
dc.contributor.author | S H Jung | - |
dc.contributor.author | Kyeong Lee | - |
dc.contributor.author | S S Han | - |
dc.contributor.author | G Y Song | - |
dc.contributor.author | Y Choi | - |
dc.date.accessioned | 2017-04-19T09:14:00Z | - |
dc.date.available | 2017-04-19T09:14:00Z | - |
dc.date.issued | 2009 | - |
dc.identifier.issn | 0253-2964 | - |
dc.identifier.uri | 10.5012/bkcs.2009.30.5.1088 | ko |
dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/8994 | - |
dc.description.abstract | A series of 2-alkyl or 2-arylthio-5,8-dimethoxy-1,4-naphthoquinones (2-Thio-DMNQ, 5a-s) and 2-alkylamino-5,8-dimethoxy-1,4-naphthoquinones (2-Amino-DMNQ, 6a-k) was synthesized and evaluated for their ACAT inhibitory activities. Among them, the 2-dodecylthio-DMNQ 5l and 2-isobutylamidoundodecylthio-DMNQ 5r showed the most potent ACAT inhibitory activities with IC50 value of 22.8 and 24.4 μM, respectively. In a structure-activity relationship study, 2-thio-DMNQs with side chains of carbon number 11 ~ 15 exhibited significant ACAT inhibitory activities. | - |
dc.publisher | Wiley | - |
dc.title | 2-substitiuted thio- and amino-5,8-dimethoxy-1,4-naphthoquinones as a novel class of Acyl-CoA: cholestrol acyltransferase inhibitors | - |
dc.title.alternative | 2-substitiuted thio- and amino-5,8-dimethoxy-1,4-naphthoquinones as a novel class of Acyl-CoA: cholestrol acyltransferase inhibitors | - |
dc.type | Article | - |
dc.citation.title | Bulletin of Korean Chemical Society | - |
dc.citation.number | 5 | - |
dc.citation.endPage | 1092 | - |
dc.citation.startPage | 1088 | - |
dc.citation.volume | 30 | - |
dc.contributor.affiliatedAuthor | Jung Ho Choi | - |
dc.contributor.affiliatedAuthor | Young Kook Kim | - |
dc.contributor.affiliatedAuthor | Mun Chual Rho | - |
dc.contributor.affiliatedAuthor | Kyeong Lee | - |
dc.contributor.alternativeName | Shen | - |
dc.contributor.alternativeName | 최정호 | - |
dc.contributor.alternativeName | Gajulapati | - |
dc.contributor.alternativeName | 이지현 | - |
dc.contributor.alternativeName | 김영국 | - |
dc.contributor.alternativeName | 노문철 | - |
dc.contributor.alternativeName | 정상훈 | - |
dc.contributor.alternativeName | 이경 | - |
dc.contributor.alternativeName | 한성식 | - |
dc.contributor.alternativeName | 송규용 | - |
dc.contributor.alternativeName | 최용석 | - |
dc.identifier.bibliographicCitation | Bulletin of Korean Chemical Society, vol. 30, no. 5, pp. 1088-1092 | - |
dc.identifier.doi | 10.5012/bkcs.2009.30.5.1088 | - |
dc.subject.keyword | naphthoquinones | - |
dc.subject.keyword | mast cells, acyl CoA | - |
dc.subject.keyword | Cholestrol Acyl Transferase (ACAT) | - |
dc.subject.keyword | structure-activity | - |
dc.subject.local | naphthoquinones | - |
dc.subject.local | mast cells, acyl CoA | - |
dc.subject.local | ACAT (acyl-CoA: cholesterol acyltransferase) | - |
dc.subject.local | Acyl-CoA:cholesterol acyltransferase (ACAT) | - |
dc.subject.local | cholesterol acytransferase (ACAT) | - |
dc.subject.local | Cholestrol Acyl Transferase (ACAT) | - |
dc.subject.local | Acyl CoA: cholesterol acyltransferase (ACAT) | - |
dc.subject.local | ACAT (Acyl-CoA:cholesterol acyltransferase) | - |
dc.subject.local | Acyl-CoA:cholesterol acyltransferase | - |
dc.subject.local | ACAT | - |
dc.subject.local | Acyl-CoA: cholesterol acyltransferase | - |
dc.subject.local | acyl-CoA:cholesterol acyltransferase (ACAT) | - |
dc.subject.local | Acyl-CoA: cholesterol acyltransferase (ACAT) | - |
dc.subject.local | Acyl-coenzyme A: cholesterol acyltransferase (ACAT) | - |
dc.subject.local | Cholesterol acytransferase (ACAT) | - |
dc.subject.local | cholestrol acyl transferase (ACAT) | - |
dc.subject.local | structure-activity | - |
dc.description.journalClass | Y | - |
There are no files associated with this item.
Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.