Antifungal activity of CHE-23C, a dimeric sesquiterpene from Chloranthus henryi

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dc.contributor.authorYon Mi Lee-
dc.contributor.authorJae Sun Moon-
dc.contributor.authorB S Yun-
dc.contributor.authorK D Park-
dc.contributor.authorG J Choi-
dc.contributor.authorJ C Kim-
dc.contributor.authorS H Lee-
dc.contributor.authorSung Uk Kim-
dc.date.accessioned2017-04-19T09:14:00Z-
dc.date.available2017-04-19T09:14:00Z-
dc.date.issued2009-
dc.identifier.issn00218561-
dc.identifier.uri10.1021/jf900674yko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/8996-
dc.description.abstractAn antifungal compound was isolated from methanol extracts of stems and roots of Chloranthus henryi Hemsl. using ethyl acetate extraction and various chromatographic techniques. On the basis of spectroscopic analyses including mass and various NMR, the structure of the compound was identified as a dimeric sesquiterpene, CHE-23C. The compound showed potent antifungal activities (MICs = 1-32 μg/mL) in vitro against various phytopathogenic fungi such as Alternaria kikuchiana, Botrytis cinerea, Colletotrichum lagenarium, Magnaporthe grisea, Pythium ultimum, and Phytophthora infestans. In particular, it exhibited 91 and 100% disease-control activity in vivo against tomato late blight (P. infestans) and wheat leaf rust (Puccinia recondita) at concentrations of 33 and 100 μg/mL, respectively. The disease-control activity of this compound was stronger than that of the commercially available fungicide chlorothalonil, but weaker than that of dimethomorph. Therefore, the compound might serve as an interesting lead to develop effective antifungal agents.-
dc.publisherAmer Chem Soc-
dc.titleAntifungal activity of CHE-23C, a dimeric sesquiterpene from Chloranthus henryi-
dc.title.alternativeAntifungal activity of CHE-23C, a dimeric sesquiterpene from Chloranthus henryi-
dc.typeArticle-
dc.citation.titleJournal of Agricultural and Food Chemistry-
dc.citation.number13-
dc.citation.endPage5755-
dc.citation.startPage5750-
dc.citation.volume57-
dc.contributor.affiliatedAuthorJae Sun Moon-
dc.contributor.alternativeName이윤미-
dc.contributor.alternativeName문제선-
dc.contributor.alternativeName윤봉식-
dc.contributor.alternativeName박기덕-
dc.contributor.alternativeName최경자-
dc.contributor.alternativeName김진철-
dc.contributor.alternativeName이상한-
dc.contributor.alternativeName김성욱-
dc.identifier.bibliographicCitationJournal of Agricultural and Food Chemistry, vol. 57, no. 13, pp. 5750-5755-
dc.identifier.doi10.1021/jf900674y-
dc.subject.keywordchloranthus henryi-
dc.subject.keywordCHE-23C-
dc.subject.keywordantifungal activity-
dc.subject.keywordphytophthora infestans-
dc.subject.keywordpuccinia recondita-
dc.subject.localchloranthus henryi-
dc.subject.localCHE-23C-
dc.subject.localantifungal activity-
dc.subject.localAntifungal activity-
dc.subject.localphytophthora infestans-
dc.subject.localPhytophthora infestans-
dc.subject.localpuccinia recondita-
dc.description.journalClassY-
Appears in Collections:
Division of Biomaterials Research > Plant Systems Engineering Research > 1. Journal Articles
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