Role of IL-10 deficiency in pneumonia induced by Corynebacterium kutscheri in mice

Cited 12 time in scopus
Metadata Downloads
Role of IL-10 deficiency in pneumonia induced by Corynebacterium kutscheri in mice
E S Jeong; Young Suk WonHyoung-Chin Kim; M H Cho; Y K Choi
Bibliographic Citation
Journal of Microbiology and Biotechnology, vol. 19, no. 4, pp. 424-430
Publication Year
IL-10 is an important anti-inflammatory cytokine that can inhibit the production of many pro-inflammatory cytokines. Both human and animal studies have shown that pro-inflammatory cytokines play an important role in pneumonia and other inflammatory lung diseases. In the present study, IL-10 knockout (KO) and wild-type mice were infected with Corynebacterium kutscheri to determine whether the severity of pathogenesis and whether protective immunity could be altered in the absence of IL-10. The survival rate was significantly lower in IL-10 KO mice than wild-type mice. The number of neutrophils in bronchoalveolar lavage fluid and blood were found to be higher in IL-10 KO mice than wild-type mice. IL-10 KO mice showed greater neutrophil infiltration, excessive inflammation, and weight-loss compared with wild-type mice. Furthermore, upregulation of IFN-γ in bronchoalveolar lavage fluid, and upregulation of MIP-1α and IP-10 mRNA in the lungs of IL-10 KO mice compared with wild-type mice after C. kutscheri infection were observed. These results suggest that IL-10 plays an important role in the anti-inflammatory properties against C. kutscheri infection, and that lack of IL-10 leads to a more severe pulmonary inflammatory response. This increased susceptibility to C. kutscheri pneumonia is at least in part caused by IL-10 deficiency and severe recruitment of neutrophils.
Corynebacterium kutscheriIFN-γ, MIP-1αIL-10 KOIP-10
Korea Soc-Assoc-Inst
Appears in Collections:
Ochang Branch Institute > Division of National Bio-Infrastructure > Laboratory Animal Resource & Research Center > 1. Journal Articles
Files in This Item:
  • There are no files associated with this item.

Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.