DC Field | Value | Language |
---|---|---|
dc.contributor.author | J A Kim | - |
dc.contributor.author | Y J Kang | - |
dc.contributor.author | G Park | - |
dc.contributor.author | M Kim | - |
dc.contributor.author | Y O Park | - |
dc.contributor.author | H Kim | - |
dc.contributor.author | S H Leem | - |
dc.contributor.author | In-Sun Chu | - |
dc.contributor.author | J S Lee | - |
dc.contributor.author | E H Jho | - |
dc.contributor.author | I H Oh | - |
dc.date.accessioned | 2017-04-19T09:14:06Z | - |
dc.date.available | 2017-04-19T09:14:06Z | - |
dc.date.issued | 2009 | - |
dc.identifier.issn | 1066-5099 | - |
dc.identifier.uri | 10.1002/stem.52 | ko |
dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/9031 | - |
dc.description.abstract | With contrasting observations on the effects of β-catenin on hematopoietic stem cells (HSCs), the precise role of Wnt/β-catenin signals on HSC regulation remains unclear. Here, we show a distinct mode of Wnt/β-catenin signal that can regulate HSCs in a stroma-dependent manner. Stabilization of β-catenin in the bone marrow stromal cells promoted maintenance and self-renewal of HSCs in a contact-dependent manner, whereas direct stabilization in hematopoietic cells caused loss of HSCs. Interestingly, canonical Wnt receptors and β-catenin accumulation were predominantly enriched in the stromal rather than the hematopoietic compartment of bone marrows. Moreover, the active form of β-catenin accumulated selectively in the trabecular endosteum in "Wnt 3a-stimulated" or "irradiationstressed," but not in "steady-state" marrows. Notably, notch ligands were induced in Wnt/β-catenin activated bone marrow stroma and downstream notch signal activation was seen in the HSCs in contact with the activated stroma. Taken together, Wnt/β-catenin activated stroma and their cross-talk with HSCs may function as a physiologically regulated microenvironmental cue for HSC self-renewal in the stem cell niche. | - |
dc.publisher | Wiley | - |
dc.title | Identification of a stroma-mediated Wnt/β-catenin signal promoting self-renewal of hematopoietic stem cells in the stem cell niche | - |
dc.title.alternative | Identification of a stroma-mediated Wnt/β-catenin signal promoting self-renewal of hematopoietic stem cells in the stem cell niche | - |
dc.type | Article | - |
dc.citation.title | Stem Cells | - |
dc.citation.number | 6 | - |
dc.citation.endPage | 1329 | - |
dc.citation.startPage | 1318 | - |
dc.citation.volume | 27 | - |
dc.contributor.affiliatedAuthor | In-Sun Chu | - |
dc.contributor.alternativeName | 김 | - |
dc.contributor.alternativeName | 강 | - |
dc.contributor.alternativeName | 박 | - |
dc.contributor.alternativeName | 김 | - |
dc.contributor.alternativeName | 박 | - |
dc.contributor.alternativeName | 김 | - |
dc.contributor.alternativeName | 임 | - |
dc.contributor.alternativeName | 추인선 | - |
dc.contributor.alternativeName | 이 | - |
dc.contributor.alternativeName | 조 | - |
dc.contributor.alternativeName | 오 | - |
dc.identifier.bibliographicCitation | Stem Cells, vol. 27, no. 6, pp. 1318-1329 | - |
dc.identifier.doi | 10.1002/stem.52 | - |
dc.subject.keyword | Hematopoietic stem cell | - |
dc.subject.keyword | Self-renewal | - |
dc.subject.keyword | Stem cell-microenvironment interactions | - |
dc.subject.keyword | Stroma | - |
dc.subject.keyword | WNT | - |
dc.subject.local | Hematopoietic stem cell | - |
dc.subject.local | hematopoietic stem cell | - |
dc.subject.local | Hematopoietic stem cells | - |
dc.subject.local | Self-renewal | - |
dc.subject.local | self-renewal | - |
dc.subject.local | Stem cell-microenvironment interactions | - |
dc.subject.local | Stroma | - |
dc.subject.local | Wnt | - |
dc.subject.local | WNT | - |
dc.subject.local | WNTs | - |
dc.description.journalClass | Y | - |
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