Identification of a stroma-mediated Wnt/β-catenin signal promoting self-renewal of hematopoietic stem cells in the stem cell niche

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dc.contributor.authorJ A Kim-
dc.contributor.authorY J Kang-
dc.contributor.authorG Park-
dc.contributor.authorM Kim-
dc.contributor.authorY O Park-
dc.contributor.authorH Kim-
dc.contributor.authorS H Leem-
dc.contributor.authorIn-Sun Chu-
dc.contributor.authorJ S Lee-
dc.contributor.authorE H Jho-
dc.contributor.authorI H Oh-
dc.date.accessioned2017-04-19T09:14:06Z-
dc.date.available2017-04-19T09:14:06Z-
dc.date.issued2009-
dc.identifier.issn1066-5099-
dc.identifier.uri10.1002/stem.52ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/9031-
dc.description.abstractWith contrasting observations on the effects of β-catenin on hematopoietic stem cells (HSCs), the precise role of Wnt/β-catenin signals on HSC regulation remains unclear. Here, we show a distinct mode of Wnt/β-catenin signal that can regulate HSCs in a stroma-dependent manner. Stabilization of β-catenin in the bone marrow stromal cells promoted maintenance and self-renewal of HSCs in a contact-dependent manner, whereas direct stabilization in hematopoietic cells caused loss of HSCs. Interestingly, canonical Wnt receptors and β-catenin accumulation were predominantly enriched in the stromal rather than the hematopoietic compartment of bone marrows. Moreover, the active form of β-catenin accumulated selectively in the trabecular endosteum in "Wnt 3a-stimulated" or "irradiationstressed," but not in "steady-state" marrows. Notably, notch ligands were induced in Wnt/β-catenin activated bone marrow stroma and downstream notch signal activation was seen in the HSCs in contact with the activated stroma. Taken together, Wnt/β-catenin activated stroma and their cross-talk with HSCs may function as a physiologically regulated microenvironmental cue for HSC self-renewal in the stem cell niche.-
dc.publisherWiley-
dc.titleIdentification of a stroma-mediated Wnt/β-catenin signal promoting self-renewal of hematopoietic stem cells in the stem cell niche-
dc.title.alternativeIdentification of a stroma-mediated Wnt/β-catenin signal promoting self-renewal of hematopoietic stem cells in the stem cell niche-
dc.typeArticle-
dc.citation.titleStem Cells-
dc.citation.number6-
dc.citation.endPage1329-
dc.citation.startPage1318-
dc.citation.volume27-
dc.contributor.affiliatedAuthorIn-Sun Chu-
dc.contributor.alternativeName-
dc.contributor.alternativeName-
dc.contributor.alternativeName-
dc.contributor.alternativeName-
dc.contributor.alternativeName-
dc.contributor.alternativeName-
dc.contributor.alternativeName-
dc.contributor.alternativeName추인선-
dc.contributor.alternativeName-
dc.contributor.alternativeName-
dc.contributor.alternativeName-
dc.identifier.bibliographicCitationStem Cells, vol. 27, no. 6, pp. 1318-1329-
dc.identifier.doi10.1002/stem.52-
dc.subject.keywordHematopoietic stem cell-
dc.subject.keywordSelf-renewal-
dc.subject.keywordStem cell-microenvironment interactions-
dc.subject.keywordStroma-
dc.subject.keywordWNT-
dc.subject.localHematopoietic stem cell-
dc.subject.localhematopoietic stem cell-
dc.subject.localHematopoietic stem cells-
dc.subject.localSelf-renewal-
dc.subject.localself-renewal-
dc.subject.localStem cell-microenvironment interactions-
dc.subject.localStroma-
dc.subject.localWnt-
dc.subject.localWNT-
dc.subject.localWNTs-
dc.description.journalClassY-
Appears in Collections:
Division of Biomedical Research > Metabolic Regulation Research Center > 1. Journal Articles
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