DC Field | Value | Language |
---|---|---|
dc.contributor.author | In-Seong Song | - |
dc.contributor.author | Sun-Uk Kim | - |
dc.contributor.author | Nang-Su Oh | - |
dc.contributor.author | J Kim | - |
dc.contributor.author | Dae Yeul Yu | - |
dc.contributor.author | S M Huang | - |
dc.contributor.author | J M Kim | - |
dc.contributor.author | D S Lee | - |
dc.contributor.author | Nam-Soon Kim | - |
dc.date.accessioned | 2017-04-19T09:14:08Z | - |
dc.date.available | 2017-04-19T09:14:08Z | - |
dc.date.issued | 2009 | - |
dc.identifier.issn | 0143-3334 | - |
dc.identifier.uri | 10.1093/carcin/bgp104 | ko |
dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/9041 | - |
dc.description.abstract | Reactive oxygen species (ROS) have been implicated in tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) resistance of many cancers. We evaluated the role of peroxiredoxin (Prx) I in TRAIL resistance governed by coupling of nicotinamide adenosine dinucleotide phosphate oxidase (Nox)-derived ROS signaling with the p38 mitogen-activated protein kinase (MAPK)/caspase-signaling cascade in liver cancer cells. Upregulated Prx I expression was found in neoplastic regions of human patient liver, and Prx I knockdown resulted in accelerated TRAIL-induced cell death in SK-Hep-1 human hepatoma cells. The TRAIL cytotoxicity by Prx I knockdown was dependent on activation of caspase-8/3 cascades, which was ablated by addition of inhibitors for p38 MAPK, ROS or Nox, suggesting the association with Nox-driven redox signaling. Furthermore, we found that Nox4 was constitutively expressed in both SK-Hep-1 cells and tumor regions of patient livers, knockdown of Nox4 expression could alleviate ROS generation and TRAIL-mediated cytotoxicity. In accordance with previous findings, increased activation of both p38 MAPK and caspase cascades by Prx I knockdown was inhibited by either Nox4 knockdown or SB203580 addition. Collectively, these data suggest that Prx I functions to block propagation of Nox-derived ROS signaling to the p38 MAPK/caspase/cell death cascade during TRAIL treatment and also provides a molecular mechanism by which Prx I contributes to TRAIL resistance in liver cancers. | - |
dc.publisher | Oxford Univ Press | - |
dc.title | Peroxiredoxin I contributes to TRAIL resistance through suppression of redox-sensitive caspase activation in human hepatoma cells | - |
dc.title.alternative | Peroxiredoxin I contributes to TRAIL resistance through suppression of redox-sensitive caspase activation in human hepatoma cells | - |
dc.type | Article | - |
dc.citation.title | Carcinogenesis | - |
dc.citation.number | 7 | - |
dc.citation.endPage | 1114 | - |
dc.citation.startPage | 1106 | - |
dc.citation.volume | 30 | - |
dc.contributor.affiliatedAuthor | In-Seong Song | - |
dc.contributor.affiliatedAuthor | Sun-Uk Kim | - |
dc.contributor.affiliatedAuthor | Nang-Su Oh | - |
dc.contributor.affiliatedAuthor | Dae Yeul Yu | - |
dc.contributor.affiliatedAuthor | Nam-Soon Kim | - |
dc.contributor.alternativeName | 송인성 | - |
dc.contributor.alternativeName | 김선욱 | - |
dc.contributor.alternativeName | 오낭수 | - |
dc.contributor.alternativeName | 김지영 | - |
dc.contributor.alternativeName | 유대열 | - |
dc.contributor.alternativeName | Huang | - |
dc.contributor.alternativeName | 김진만 | - |
dc.contributor.alternativeName | 이동석 | - |
dc.contributor.alternativeName | 김남순 | - |
dc.identifier.bibliographicCitation | Carcinogenesis, vol. 30, no. 7, pp. 1106-1114 | - |
dc.identifier.doi | 10.1093/carcin/bgp104 | - |
dc.description.journalClass | Y | - |
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