Tumor necrosis factor-α enhances IL-15-induced natural killer cell differentiation

Cited 7 time in scopus
Metadata Downloads
Title
Tumor necrosis factor-α enhances IL-15-induced natural killer cell differentiation
Author(s)
Jiwon Lee; Suk Hyung Lee; N Shin; Mi-Ra Jeong; Mi Sun Kim; Mi-Joung Kim; Suk Ran Yoon; J W Chung; Tae-Don KimIn Pyo Choi
Bibliographic Citation
Biochemical and Biophysical Research Communications, vol. 386, no. 4, pp. 718-723
Publication Year
2009
Abstract
The differentiation of natural killer (NK) cells is regulated by various factors including soluble growth factors and transcription factors. Here, we have demonstrated that tumor necrosis factor-a (TNF-α) is a positive regulator of NK cell differentiation. TNF-α augmented the IL-15-induced expression of NK1.1 and CD122 in mature NK cells, and TNF-α alone also induced NK cell maturation as well as IL-15. TNF-α also increased IFN-γ production in NK cells in the presence of IL-15. Meanwhile, mRNA expression of several transcription factors, including T-bet and GATA-3, was increased by the addition of TNF-α and IL-15. In addition, TNF-α increased nuclear factor-kappa B (NF-κB) activity in NK cells and inhibition of NF-κB impeded TNF-α-enhanced NK cell maturation. Overall, these data suggest that TNF-α significantly increased IL-15-driven NK cell differentiation by increasing the expression of transcription factors that play crucial roles in NK cell maturation and inducing the NF-κB activity.
Keyword
TNF-aNK cellsDifferentiationT-betGATA-3NF-κB
ISSN
0006-291X
Publisher
Elsevier
DOI
http://dx.doi.org/10.1016/j.bbrc.2009.06.120
Type
Article
Appears in Collections:
Division of Biomedical Research > Immunotherapy Research Center > 1. Journal Articles
Files in This Item:
  • There are no files associated with this item.


Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.