Structure-based de novo design and biochemical evaluation of novel Cdc25 phosphatase inhibitors

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dc.contributor.authorH Park-
dc.contributor.authorY J Bahn-
dc.contributor.authorSeong Eon Ryu-
dc.date.accessioned2017-04-19T09:14:08Z-
dc.date.available2017-04-19T09:14:08Z-
dc.date.issued2009-
dc.identifier.issn0960-894X-
dc.identifier.uri10.1016/j.bmcl.2009.05.084ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/9046-
dc.description.abstractCdc25 phosphatases have been considered as attractive drug targets for anticancer therapy due to the correlation of their overexpression with a wide variety of cancers. We have been able to identify 32 novel Cdc25 phosphatase inhibitors with micromolar activity by means of a structure-based de novo design method with the two known inhibitor scaffolds. Because the newly discovered inhibitors are structurally diverse and have desirable physicochemical properties as a drug candidate, they deserve further investigation as anticancer drugs. The differences in binding modes of the identified inhibitors in the active sites of Cdc25A and B are addressed in detail.-
dc.publisherElsevier-
dc.titleStructure-based de novo design and biochemical evaluation of novel Cdc25 phosphatase inhibitors-
dc.title.alternativeStructure-based de novo design and biochemical evaluation of novel Cdc25 phosphatase inhibitors-
dc.typeArticle-
dc.citation.titleBioorganic & Medicinal Chemistry Letters-
dc.citation.number15-
dc.citation.endPage4334-
dc.citation.startPage4330-
dc.citation.volume19-
dc.contributor.affiliatedAuthorSeong Eon Ryu-
dc.contributor.alternativeName박황서-
dc.contributor.alternativeName반영재-
dc.contributor.alternativeName류성언-
dc.identifier.bibliographicCitationBioorganic & Medicinal Chemistry Letters, vol. 19, no. 15, pp. 4330-4334-
dc.identifier.doi10.1016/j.bmcl.2009.05.084-
dc.subject.keywordCdc25 phosphatase-
dc.subject.keywordDe novo design-
dc.subject.keywordDocking-
dc.subject.keywordAnticancer agents-
dc.subject.localCdc25 phosphatase-
dc.subject.localDe novo design-
dc.subject.localde novo design-
dc.subject.localDocking-
dc.subject.localdocking-
dc.subject.localAnti-cancer agent-
dc.subject.localAnti-cancer agents-
dc.subject.localAnticancer agent-
dc.subject.localAnticancer agents-
dc.subject.localAnticancer Agents-
dc.subject.localanti-cancer agent-
dc.subject.localAnticancer Agent-
dc.subject.localanticancer agent-
dc.description.journalClassY-
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