DC Field | Value | Language |
---|---|---|
dc.contributor.author | H Park | - |
dc.contributor.author | Y J Bahn | - |
dc.contributor.author | Seong Eon Ryu | - |
dc.date.accessioned | 2017-04-19T09:14:08Z | - |
dc.date.available | 2017-04-19T09:14:08Z | - |
dc.date.issued | 2009 | - |
dc.identifier.issn | 0960-894X | - |
dc.identifier.uri | 10.1016/j.bmcl.2009.05.084 | ko |
dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/9046 | - |
dc.description.abstract | Cdc25 phosphatases have been considered as attractive drug targets for anticancer therapy due to the correlation of their overexpression with a wide variety of cancers. We have been able to identify 32 novel Cdc25 phosphatase inhibitors with micromolar activity by means of a structure-based de novo design method with the two known inhibitor scaffolds. Because the newly discovered inhibitors are structurally diverse and have desirable physicochemical properties as a drug candidate, they deserve further investigation as anticancer drugs. The differences in binding modes of the identified inhibitors in the active sites of Cdc25A and B are addressed in detail. | - |
dc.publisher | Elsevier | - |
dc.title | Structure-based de novo design and biochemical evaluation of novel Cdc25 phosphatase inhibitors | - |
dc.title.alternative | Structure-based de novo design and biochemical evaluation of novel Cdc25 phosphatase inhibitors | - |
dc.type | Article | - |
dc.citation.title | Bioorganic & Medicinal Chemistry Letters | - |
dc.citation.number | 15 | - |
dc.citation.endPage | 4334 | - |
dc.citation.startPage | 4330 | - |
dc.citation.volume | 19 | - |
dc.contributor.affiliatedAuthor | Seong Eon Ryu | - |
dc.contributor.alternativeName | 박황서 | - |
dc.contributor.alternativeName | 반영재 | - |
dc.contributor.alternativeName | 류성언 | - |
dc.identifier.bibliographicCitation | Bioorganic & Medicinal Chemistry Letters, vol. 19, no. 15, pp. 4330-4334 | - |
dc.identifier.doi | 10.1016/j.bmcl.2009.05.084 | - |
dc.subject.keyword | Cdc25 phosphatase | - |
dc.subject.keyword | De novo design | - |
dc.subject.keyword | Docking | - |
dc.subject.keyword | Anticancer agents | - |
dc.subject.local | Cdc25 phosphatase | - |
dc.subject.local | De novo design | - |
dc.subject.local | de novo design | - |
dc.subject.local | Docking | - |
dc.subject.local | docking | - |
dc.subject.local | Anti-cancer agent | - |
dc.subject.local | Anti-cancer agents | - |
dc.subject.local | Anticancer agent | - |
dc.subject.local | Anticancer agents | - |
dc.subject.local | Anticancer Agents | - |
dc.subject.local | anti-cancer agent | - |
dc.subject.local | Anticancer Agent | - |
dc.subject.local | anticancer agent | - |
dc.description.journalClass | Y | - |
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