Hypopigmentary effect of milk thistle extract silymarin = 엉겅퀴 추출물 실리마린의 피부 미백효과

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dc.contributor.authorSoo-Jin Choo-
dc.contributor.authorIn Ja Ryoo-
dc.contributor.authorYoung Hee Kim-
dc.contributor.authorG H Xu-
dc.contributor.authorK H Kim-
dc.contributor.authorC S Han-
dc.contributor.authorS J Kim-
dc.contributor.authorJ W Kim-
dc.contributor.authorE D Son-
dc.contributor.authorIck Dong Yoo-
dc.date.accessioned2017-04-19T09:14:12Z-
dc.date.available2017-04-19T09:14:12Z-
dc.date.issued2009-
dc.identifier.issnI000-0160-
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/9051-
dc.description.abstractWe found that silymarin exhibited the inhibitory effect on melanogenesis in a spontaneously immortalized mouse melanocyte cell line, Mel-Ab. Silymarin is a standardized extract obtained from the dried seeds of milk thistle (Silybum marianum Gaertn.). Silymarin significantly prevented melanin production in a dose-dependent manner with an value of 28.2 without effects on cell viability. Also, silymarin inhibited tyrosinase activity in melanocyte, while it did not affect the catalytic activity of cell-free tyrosinase. Furthermore, Western blot analysis indicated that silymarin decreased the expression of tyrosinase protein. Silybin A/B and isosilybin A/B were also able to inhibit melanin production and tyrosinase expression in protein level. Double blind study on the clinical efficacy of a cream containing 2 % silymarin showed that silymarin have a significant skin whitening effect. Therefore, this study suggests that silymarin may be useful as a natural skin whitening agent.-
dc.publisherKorea Soc-Assoc-Inst-
dc.titleHypopigmentary effect of milk thistle extract silymarin = 엉겅퀴 추출물 실리마린의 피부 미백효과-
dc.title.alternativeHypopigmentary effect of milk thistle extract silymarin-
dc.typeArticle-
dc.citation.titleJournal of Society of Cosmetic Scientists of Korea (Old)-
dc.citation.number2-
dc.citation.endPage158-
dc.citation.startPage151-
dc.citation.volume35-
dc.contributor.affiliatedAuthorSoo-Jin Choo-
dc.contributor.affiliatedAuthorIn Ja Ryoo-
dc.contributor.affiliatedAuthorYoung Hee Kim-
dc.contributor.affiliatedAuthorG H Xu-
dc.contributor.affiliatedAuthorIck Dong Yoo-
dc.contributor.alternativeName추수진-
dc.contributor.alternativeName류인자-
dc.contributor.alternativeName김영희-
dc.contributor.alternativeName허광화-
dc.contributor.alternativeName김기호-
dc.contributor.alternativeName한창성-
dc.contributor.alternativeName김수진-
dc.contributor.alternativeName김진웅-
dc.contributor.alternativeName손의동-
dc.contributor.alternativeName유익동-
dc.identifier.bibliographicCitationJournal of Society of Cosmetic Scientists of Korea (Old), vol. 35, no. 2, pp. 151-158-
dc.subject.keywordmelanogenesis-
dc.subject.keywordsilymarin-
dc.subject.keywordtyrosinase activity-
dc.subject.keywordsilybin-
dc.subject.keywordskin whitening-
dc.subject.localmelanogenesis-
dc.subject.localMelanogenesis-
dc.subject.localsilymarin-
dc.subject.localSilymarin-
dc.subject.localtyrosinase activity-
dc.subject.localTyrosinase activity-
dc.subject.localsilybin-
dc.subject.localSkin Whitening-
dc.subject.localskin-whitening-
dc.subject.localskin whitening-
dc.subject.localSkin-whitening-
dc.description.journalClassN-
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Ochang Branch Institute > Chemical Biology Research Center > 1. Journal Articles
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